程序性细胞死亡在青光眼视网膜神经节细胞中的研究进展

Advances in the role of programmed cell death in retinal ganglion cells in glaucoma

程序性细胞死亡(PCD)不同于传统意义上的细胞坏死,是涉及效应分子参与的独特的细胞死亡方式,包括细胞凋亡、自噬和焦亡等多种形式。PCD参与人类正常生理活动的诸多环节,更与多种疾病的发生发展密切相关。青光眼是全球不可逆失明的主要原因。相关研究表明,青光眼的发生与多种PCD的相关蛋白异常表达有关。文章将对青光眼发病过程中视网膜神经节细胞的凋亡、自噬、焦亡、铁死亡及依赖性细胞死亡相关机制及其相互作用作一综述,为青光眼的防治提供新思路。

Programmed cell death(PCD)is a unique cell death involving effector molecules,including various forms such as apoptosis,autophagy,and pyroptosis.PCD is involved in many aspects of normal physiological activities in humans,and is closely related to the development of many diseases.Glaucoma is the leading cause of irreversible blindness worldwide.Relevant studies have shown that the development of glaucoma is associated with the abnormal expression of a variety of PCD-related proteins.The mechanism and interplay of apoptosis,autophagy,pyroptosis,ferroptosis and parthanatos of retinal ganglion cells in the course of glaucoma were reviewed,to provide a new direction for the prevention treatment of glaucoma.