中药黄酮治疗帕金森病基础研究进展

Research Progress in TCM Flavonoids for the Treatment of Parkinson Disease

帕金森病是常见神经退行性疾病,目前主要治疗药物存在不良反应大、靶向性欠缺、生物利用度较低等问题,新药研发是帕金森病相关研究的重要方向。中药黄酮具有多种药理活性,在抗肿瘤和心血管疾病治疗方面应用广泛,但其干预神经系统疾病相关研究偏少。本文从中药黄酮类、黄酮醇、异黄酮、黄酮苷、二氢黄酮醇及其他共6类,阐述近年中药黄酮干预帕金森病的作用机制并归纳治疗策略,以期为中药黄酮药物研发和临床应用提供参考。

Parkinson disease is a common neurodegenerative disease.At present,the main therapeutic drugs have problems such as adverse reactions,lack of targeting,and low bioavailability.The development of new drugs is an important direction for research related to Parkinson disease.TCM flavonoids have various pharmacological activities and are widely used in anti-tumor and cardiovascular disease treatment,but there is relatively little research on their intervention in neurological diseases.This article elaborated on the mechanism of intervention of TCM flavonoids in Parkinson disease and summarized treatment strategies from six categories:flavonoids,flavonols,isoflavones,flavonoid glycosides,dihydroflavonols,and others,with the purpose to provide reference for the research and clinical application of TCM flavonoids.