老年乳腺癌患者化疗后消化系统损害的影响因素及其与生活质量的相关性

Influencing factors of digestive system damage after chemotherapy and correlation with quality of life in elderly patients with breast cancer

目的分析老年乳腺癌患者化疗后消化系统损害的影响因素,并探讨消化系统损害与生活质量的相关性。方法选取首都医科大学附属北京世纪坛医院2019年8月至2023年4月收治的90例老年乳腺癌患者为研究对象。收集患者基础资料、肿瘤特征、药物使用情况及生化指标等临床资料。根据消化系统损害情况,将患者分为消化系统严重损害组(中重度消化系统损害,n=27)和消化系统非严重损害组(无消化系统损害或轻度消化系统损害,n=63)。采用世界卫生组织生活质量测定量表-100评估患者生活质量情况。采用SPSS 26.0统计软件进行数据分析。采用单因素和多因素logistic回归分析老年乳腺癌患者化疗后消化系统损害的影响因素。采用Spearman相关性分析评估患者消化系统损害与生活质量的相关性。结果消化系统严重损害组年龄、高血压、乳腺癌病程、肿瘤-淋巴结-转移分期及化疗疗程与消化系统非严重损害组比较,差异均有统计学意义(均P<0.05)。多因素logistic回归分析结果显示,年龄(OR=2.815,95%CI 1.268~6.251)及化疗疗程(OR=2.675,95%CI 1.255~5.701)是老年乳腺癌患者化疗后消化系统损害的影响因素(均P<0.05)。老年乳腺癌患者生活质量评分为(53.81±4.76)分。Spearman相关性分析显示,老年乳腺癌患者消化系统损害与生活质量呈负相关(r=-0.741;P<0.05)。结论老年乳腺癌患者化疗后消化系统损害的影响因素较多,临床上应对存在高危因素的患者加强关注。

Objective To analyze the influencing factors of digestive system damage after chemotherapy in elderly patients with breast cancer,and explore the correlation between digestive system damage and quality of life.Methods A total of 90 elderly patients with breast cancer admitted to our hospital from August 2019 to April 2023 were enrolled.Their clinical data,including basic information,tumor features,drug use,biochemical indicators and other indicators were collected.According to the severity of digestive system damage,they were divided into severe group(moderate to severe,n=27)and non-damage group(no or mild damage).World Health Organization quality of life scale-100 was applied to evaluate their quality of life.SPSS 26.0 was used for statistical analysis.Univariate and multivariate logistic regression were employed to analyze the influencing factors for digestive system damage in these elderly patients.Spearman correlation analysis was conducted to evaluate the correlation between the damage and quality of life of patients.Results Significant differences were observed between the severe group and the non-damage group in terms of age,hypertension,course of breast cancer,tumor node metastasis stage and chemotherapy course(all P<0.05).Multivariate logistic regression analysis showed that age(OR=2.815,95%CI 1.268-6.251)and duration of chemotherapy(OR=2.675,95%CI 1.255-5.701)were the influencing factors of digestive system damage in the patients(P<0.05).The quality of life score was(53.81±4.76)in the elderly breast cancer patients after chemotherapy.Spearman correlation analysis indicated that digestive system damage was negatively correlated with quality of life of the patients(r=-0.741,P<0.05).Conclusion There are many factors affecting digestive system damage in elderly patients with breast cancer after chemotherapy.More attention should be paid to those with high risk factors in clinical practice.