阿普米司特治疗弥漫性斑秃一例并文献复习

Alopecia areata treated with apremilast:a case report and literature review

斑秃传统治疗包括糖皮质激素、米诺地尔、中医药、免疫抑制剂等,但达不到满意疗效。阿普米司特是一种口服小分子磷酸二酯酶4抑制剂,国外有阿普米司特可显著改善斑秃的报道。国内暂无阿普米司特治疗斑秃的报道,本文报道一例阿普米司特成功治疗弥漫性斑秃的患者,给予阿普米司特30 mg每日2次治疗,14周后毛发全部长出,均为黑发。随访2个月未复发,未见药物不良反应。

The traditional treatment of alopecia areata includes glucocorticoids,minoxidil,traditional Chinese medicine,immunosuppressants,etc.,but the effect is not satisfactory.Apremilast,an oral small molecule inhibitor of phosphodiesterase 4,has been shown to significantly enhance the condition of alopecia areata according to international reports.However,there's no documented use of apremilast for treating alopecia areata in China.Herein,we report a patient with alopecia areata successfully treated with apremilast,30 mg,twice a day for 14 weeks,and the patient's hair grew back and was black.The patients were followed up for 2 months without recurrence and adverse drug reactions.