小剂量右美托咪定对女性上肢骨折手术患者止血带反应的影响

Effect of low-dose Dexmedetomidine on tourniquet reaction in female patients with upper limb fracture surgery

目的探讨小剂量右美托咪定对女性上肢骨折手术患者止血带反应的影响。方法选取广州市正骨医院2023年6月至11月收治的60例女性上肢骨折手术患者作为研究对象,采用随机数字表法分为研究组与对照组,每组各30例。两组均在超声引导下行肌间沟入路臂丛神经阻滞,研究组在阻滞前10min开始静脉泵注小剂量右美托咪定,对照组在阻滞前10 min开始静脉泵注等量生理盐水。比较两组的疼痛评分、心率(HR)与平均动脉压(MAP)、不良反应发生情况。结果研究组使用止血带后30 min的视觉模拟评分法评分较对照组低(P<0.05)。研究组使用止血带后10、30min的HR、MAP较对照组低(P<0.05)。两组阻滞后48 h内均未发生穿刺点感染、血肿、呼吸抑制等不良反应。结论静脉泵注小剂量右美托咪定可减轻女性上肢骨折手术患者的止血带反应。

Objective To explore the effect of low-dose Dexmedetomidine on tourniquet reaction in female patients with upper limb fracture surgery.Methods A total of 60 female patients with upper limb fracture surgery admitted to Guangzhou Orthopedic Hospital from June to November 2023 were selected as the study objects.All the patients were divided into the study group and the control group by the random number table method,with 30 cases in each group.The two groups underwent brachial plexus block through the interscalene approach under the guidance of ultrasound.The study group started to inject low-dose Dexmedetomidine 10 minutes before the block,and the control group started to inject the same volume of normal saline 10 minutes before the block.The pain scores,heart rate(HR)and mean arterial pressure(MAP),and incidence of adverse reactions of the two groups were compared.Results The score of visual a nalogue sc ale a t 30 mi nutes a fter using t he tourniquet in t he study g roup was l ower than that i n t he c ontrol group(P<0.05).The HR and MAP at 10 and 30 minutes after using the tourniquet in the study group were lower than those in the control group(P<0.05).There were no adverse reactions such as puncture point infection,hematoma,and respiratory depression occurred within 48 hours after block in both groups.Conclusion Intravenous infusion of lowdoses Dexmedetomidine can reduce tourniquet reaction in female patients u ndergoing upper limb fracture surgery.