高血压脑出血患者外周血白细胞、中性粒细胞、血小板计数及血脂指标与患者预后的相关性分析

Correlation Analysis of Peripheral White Blood Cells,Neutrophils,Platelet Count and Blood Lipid Index in Patients with Hypertensive Cerebral Hemorrhage

目的探讨高血压脑出血患者外周血白细胞(WBC)、中性粒细胞(NEUT)、血小板计数(PLT)及血脂指标与患者预后的相关性。方法本研究共纳入98例高血压脑出血患者,所有病例均来源于中国人民解放军联勤保障部队第九八八医院,选取时间为2020年3月至2023年1月,进行回顾性分析,所有患者入院治疗30 d后,按照患者的影像学检测显示结果与预后结局将其分为预后良好组和预后不良组,两组的例数分别为64例、34例。将预后良好组和预后不良组患者WBC、NEUT、PLT指标进行检测并对比,将预后良好组患者和预后不良组患者各项血脂相关指标水平进行检测并对比,将预后良好组和预后不良组患者美国国立卫生院卒中量表(NIHSS)评分进行对比,采用相关性分析软件分析患者血脂相关指标、血常规参数及NIHSS评分与预后的相关性。结果预后良好组患者WBC、NEUT相较于预后不良组患者下降,而预后良好组患者PLT指标水平则相较于预后不良组上升(均P<0.05);预后良好组患者TG、LDL-C指标水平均相较于预后不良组下降,而预后良好组患者HDL-C指标则相较于预后不良组升高(均P<0.05),两组患者TC指标进行对比,未见明显差异(P>0.05);预后不良组患者NIHSS评分相较于预后良好组升高(t=22.264,P<0.05);相关性软件分析得出,高血压脑出血患者TG、LDL-C、NIHSS、WBC、NEUT与预后表现为负相关关系,而HDL-C、PLT指标与预后则表现为正相关关系(r=0.481、0.441,均P<0.05)。结论高血压脑出血患者WBC、NEUT、PLT及血脂指标水平和预后之间有着密不可分的联系,上述指标水平出现异常是导致预后不良的主要因素,临床可通过密切监测上述指标,并采取针对性的措施加以干预,以改善患者预后。

Objective To investigate the correlation of peripheral blood leukocytes(WBC),neutrophils(NEUT),platelet count(PLT)and blood lipid index in patients with hypertensive cerebral hemorrhage.Methods This study included 98 cases of hypertensive cerebral hemorrhage,all cases from the PLA joint logistic support force hospital,selected from March 2020 to January 2023,all patients were divided into good prognosis and poor prognosis according to the imaging test results,and the outcome of 64 and 34 cases,respectively.The WBC,NEUT and PLT indexes were detected and compared,and the scores of patients in the group with good prognosis and the group with bad prognosis,and the correlation of NIHSS parameters and NIHSS scores.Results WBC and NEUT decreased compared with the poor prognosis group.However,the level of PLT index in patients with good prognosis increased compared with the poor prognosis group(P<0.05);the TG and LDL-C index levels were all decreased compared with the poor prognosis group,the HDL-C index in the good prognosis group was increased compared to the poor prognosis group(all P<0.05),TC indicators between the two groups,no significant difference was observed(P>0.05);the NIHSS score of patients in the poor prognosis group was increased compared to the good prognosis group(t=22.264,P<0.05);correlation software analysis concluded,the TG,LDL-C,NIHSS,WBC,and NEUT were negatively associated with the prognosis.However,HDL-C,PLT index and prognosis(r=0.481,0.441,All cases:P<0.05).Conclusion There is an inseparable link between WBC,NEUT,PLT and lipid indexes and prognosis in patients with hypertensive cerebral hemorrhage.Ababnormalities are the main factors leading to poor prognosis.Clinically,the above indexes can be closely monitored and targeted measures taken to improve the prognosis of patients.