米格列醇对2型糖尿病患者颈动脉斑块逆转作用的研究

Study on the Reversing Effect of Miglitol on Carotid Plaque in Type 2 Diabetes Patients

目的探讨米格列醇对2型糖尿病(T2DM)患者颈动脉斑块逆转作用。方法选取医院2022年5月-2023年5月收治的83例T2DM合并颈动脉斑块患者,按就诊单尾号单号设对照组(42例)、双号设研究组(41例);对照组予胰岛素治疗,研究组基于对照组予米格列醇治疗;对比两组糖代谢指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2h血糖(2h PG)]、血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎症指标[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素1-β(IL-1β)]及颈动脉斑块面积。结果治疗3个月,研究组FPG、HbA1c、2h PG、TC、TG、LDL-C、hs-CRP、TNF-α、IL-1β水平、颈动脉斑块面积较对照组低,HDL-C水平较对照组高,差异有统计学意义(P<0.05)。结论T2DM患者采用米格列醇治疗可改善糖脂代谢指标,减轻炎症反应,逆转颈动脉斑块。

Objective To investigate the reversal effect of miglitol on carotid plaque in patients with type 2 diabetes mellitus(T2DM).Method 83 patients with T2DM combined with carotid artery plaques admitted to the hospital from May 2022 to May 2023 were selected,and a control group(42 cases)and a study group(41 cases)were set up according to the tail number and single number of the treatment form;the control group was treated with insulin,while the research group was treated with Miglitaxel based on the control group;compare two groups of glucose metabolism indicators[fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),2-hour postprandial blood glucose(2h PG)],blood lipid indicators[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],inflammation indicators[hypersensitive C-reactive protein(hs CRP),tumor necrosis factor-α(TNF-α)、Interleukin 1-β(IL-1β)]And the area of carotid artery plaques.Results After 3 months of treatment,the study group had FPG,HbA1c,2h PG,TC,TG,LDL-C,hs CRP,TNF-α、IL-1β.The horizontal and carotid artery plaque area were lower than the control group,and the HDL-C level was higher than the control group,with a statistically significant difference(P<0.05).Conclusion Treatment with Miglitaxel in T2DM patients can improve glucose and lipid metabolism indicators,alleviate inflammatory reactions,and reverse carotid artery plaques.