血必净在纤维支气管镜肺泡灌洗重症肺炎治疗效果和肺功能的影响

Therapeutic Effect of Xuebijing on Severe Pneumonia and Pulmonary Function by Bronchoalveolar Lavage under Fiberoptic Bronchoscope

目的探究血必净(XBJ)联合纤维支气管镜肺泡灌洗(BAL)治疗重症肺炎的临床疗效及安全性。方法选取2020年6月至2022年12月在本院进行治疗80例重症肺炎作为研究对象,依据不同的治疗方式分为两组,其中单药组(n=40)在常规治疗的基础上行BAL,而联合组(n=40)在单药组治疗的基础上追加XBJ。对比两组患者临床疗效、临床症状消失时间、肺功能和动脉血气指标改善情况以及炎症指标水平,并记录两组患者不良反应发生情况。结果联合组临床总显效率高于单药组,并且肺部啰音、体温过高、咳嗽和胸疼等主要临床消失时间均短于单药组(P<0.05)。治疗后,联合组肺功能指标和动脉血气指标优于单药组(P<0.05)。治疗后,联合组C反应蛋白(CRP)、白介素1β(IL-1β)和IL-6水平低于单药组(P<0.05)。两组不良反应发生情况相似,对比均无明显差异(P>0.05)。结论常规治疗方案+BAL的基础上添加XBJ可安全有效治疗重症肺炎患者,并且可改善患者动脉血气指标和肺功能,并减轻炎症反应。

Objective To explore the clinical efficacy and safety of Xuebijing(XBJ)combined with fiberoptic bronchoscopic bronchoalveolar lavage(BAL)in the treatment of severe pneumonia.Methods 80 patients with severe pneumonia were treated in our hospital from June 2020 to December 2022.they were divided into two groups according to different treatment methods.The single drug group(n=40)was treated with BAL on the basis of routine treatment,while the combined group(n=40)was treated with XBJ on the basis of single drug group.The clinical efficacy,the disappearance time of clinical symptoms,the improvement of pulmonary function and arterial blood gas and the level of inflammation were compared between the two groups,and the adverse reactions of the two groups were recorded.Results the total clinical effective rate in the combination group was higher than that in the single drug group,and the main clinical disappearance time of lung rale,hyperthermia,cough and chest pain in the combination group was shorter than that in the single drug group(P<0.05).After treatment,the indexes of pulmonary function and arterial blood gas in the combined group were better than those in the single drug group(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-1β(IL-1β)and IL-6 in the combined group were lower than those in the single drug group.The adverse reactions of the two groups were similar,and there was no significant difference between the two groups(P>0.05).Conclusion adding XBJ on the basis of routine treatment plus BAL can safely and effectively treat patients with severe pneumonia,improve arterial blood gas index and pulmonary function,and reduce inflammatory reaction.