牛肺表面活性剂治疗对肺透明膜病患儿呼吸力学及预后转归的影响

Effects of Bovine Lung Surfactant Therapy on Respiratory Mechanics and Prognosis in Children with Permeable Membrane Disease

目的探究牛肺表面活性剂对肺透明膜病患儿呼吸力学及预后转归的应用效果。方法选取2021年2月-2022年2月在本院收治的NRDS患儿108例作为研究对象,按照治疗方法的不同分为44例对照组(常规治疗)和64例观察组(牛肺表面活性剂治疗)。对比两组治疗前后呼吸力学的变化情况、治疗后临床疗效以及治疗后并发症发生率。结果观察组患儿的静态肺顺应性、吸气峰流量均高于对照组(P<0.05)。两组相比,观察组患儿总有效率更高,并发症总发生率更低(P<0.05)。结论肺透明膜病患儿使用牛肺表面活性剂可以改善气体交换,能有效提升治疗效果,安全性尚可。

Objective To study the effects of bovine lung surfactant therapy on respiratory mechanics and prognosis in children with perme able membrane disease.Methods 108 children with NRDS who were admitted to our hospital from February 2021 to February 2022 were selected as study objects,and according to different treatment methods,they were divided into the control group of 44 cases(conventional treatment)and the observation group of 64 cases(bovine lung surface active agent treatment).The changes of respiratory mechanics before and after treatment,the clinical curative effect after treatment and the incidence of complications after treatment were compared between the two groups.Results The static lung compliance and peak inspiratory flow of the observation group were higher than those of the control group(P<0.05).Compared with the control group,the observation group had a higher total effective rate and a lower total incidence of complications(P<0.05).Conclusion The use of bovine lung surfactant in children with pulmonary transmembrane disease can improve gas exchange,and can effectively improve the therapeutic effect,with acceptable safety.