甲胎蛋白联合异常凝血酶原检测在肝癌早期诊断中的价值探讨

Value of Alpha-fetoprotein Combined with Abnormal Prothrombin Detection in Early Diagnosis of Liver Cancer

目的分析甲胎蛋白联合异常凝血酶原检测在肝癌早期诊断中的价值。方法选取我院2021年1月至2022年12月期间收治的50例疑似肝癌患者作为探讨对象,均给予异常凝血酶原检测,随后在此基础之上结合甲胎蛋白检测,最终均行肝组织活检并以此为标准。结果50例疑似肝癌患者经肝组织活检确诊为肝癌有48例(96.00%)。50例疑似肝癌患者中甲胎蛋白检测阳性的有44例(88.00%),甲胎蛋白结合异常凝血酶原检测同时阳性的有49例(98.00%),两者肝癌检出率相比(校正χ^(2)=2.458,P=0.117),无差异(P>0.05);甲胎蛋白检测与甲胎蛋白结合异常凝血酶原检测的灵敏度、准确度、漏诊率使用χ^(2)检验对比,分别为(校正χ^(2)=4.444,P=0.035)、(校正χ^(2)=4.396,P=0.036)、(校正χ^(2)=4.432,P=0.035),有差异(P<0.05);特异度使用Fisher确切检验(P=1.000),无差异(P>0.05)。结论甲胎蛋白与异常凝血酶原检测均对肝癌早期有一定诊断价值,但仅用甲胎蛋白判断恶性肿瘤良恶性与评估疗效的准确性、灵敏度有限,需要联合异常凝血酶原检测,利于为进一步诊治提供依据。

Objective To analyze the value of alpha-fetoprotein combined with abnormal prothrombin detection in the early diagnosis of liver cancer.Methods 50 patients with suspected liver cancer admitted to our hospital from January 2021 to December 2022 were selected as subjects.All of them were given abnormal prothrombin detection,and then combined with alpha-fetoprotein detection on this basis.Finally,liver tissue biopsy was performed and taken as the standard.Results Among the 50 suspected patients with liver cancer,48 cases(96.00%)were diagnosed with liver cancer by liver tissue biopsy.Among the 50 suspected liver cancer patients,44 cases(88.00%)were positive for alpha-fetoprotein,and 49 cases(98.00%)were positive for alpha-fetoprotein binding abnormal prothrombin.There was no difference in the detection rate of liver cancer between the two cases(correctionχ^(2)=2.458,P=0.117)(P>0.05);(P>0.05);the sensitivity,accuracy and missed diagnosis rate of alpha-fetoprotein detection and alpha-fetoprotein binding abnormal prothrobin detection were compared byχ^(2)test(correctedχ^(2)=4.444,P=0.035),(correctedχ^(2)=4.396,P=0.036),and(correctedχ^(2)=4.432,P=0.035),respectively(P<0.05).Fisher's exact test was used for specificity(P=1.000),and there was no difference(P>0.05).Conclusions Both alpha-fetoprotein and abnormal prothrombin detection have certain diagnostic value in the early stage of liver cancer,but the accuracy and sensitivity of judging benign and malignant tumors and evaluating the curative effect by using only alpha-fetoprotein are limited,so the combination of abnormal prothrombin detection is necessary to provide basis for further diagnosis and treatment.