常规治疗联合盐酸氨溴索与盐酸丙卡特罗治疗儿童肺炎支原体肺炎的效果分析

Efficacy of Routine Therapy Combined with Ambroxol Hydrochloride and Procaterol Hydrochloride in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children

目的:分析常规治疗联合盐酸氨溴索与盐酸丙卡特罗治疗儿童肺炎支原体肺炎的效果。方法:选取2022年12月—2024年5月遵义市妇幼保健院收治的肺炎支原体肺炎患儿326例作为研究对象,根据随机数字表法分成对照组与观察组,各163例。对照组接受常规治疗,观察组在对照组基础上接受盐酸氨溴索与盐酸丙卡特罗治疗。比较两组治疗效果、临床症状消失时间、炎性因子水平及肺功能。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.016)。观察组发热、咳嗽、气喘、肺部啰音消失时间短于对照组,差异有统计学意义(P<0.001)。治疗前,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平比较,差异无统计学意义(P>0.05);治疗后,两组TNF-α、IL-2水平降低,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组用力肺活量(FVC)、第1秒用力呼气容积占正常预测值的百分比(FEV1%预测值)比较,差异无统计学意义(P>0.05);治疗后,两组FVC、FEV1%预测值水平升高,观察组高于对照组,差异有统计学意义(P<0.05)。结论:常规治疗联合盐酸氨溴索与盐酸丙卡特罗治疗儿童肺炎支原体肺炎的效果显著,能够有效缓解临床症状,减轻炎性反应,改善肺功能。

Objective:To analyze the effect of conventional treatment combined with ambroxol hydrochloride and procaterol hydrochloride in the treatment of mycoplasma pneumoniae pneumonia in children.Methods:A total of three hundred and twenty�six children with mycoplasma pneumoniae pneumonia admitted to Zunyi Maternal and Child Health Hospital from December 2022 to May 2024 were selected as the study objects,and were divided into control group and observation group according to random number table method,with one hundred and sixty-three cases in each group.The control group received conventional treatment,and the observation group received ambroxol hydrochloride and procaterol hydrochloride on the basis of control group.The therapeutic effect,duration of clinical symptoms,levels of inflammatory factors and lung function were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.016).The disappearance time of fever,cough,asthma and pulmonary rales in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in tumor necrosis factor-α(TNF-α)and interleukin-2(IL-2)levels between the two groups(P>0.05);after treatment,the levels of TNF-αand IL-2 in two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,the percentage of forced vital capacity(FVC)and forced expiratory volume in the first second to the normal predicted value(FEV1%predicted value)of the two groups had no statistical significance(P>0.05);after treatment,the FVC and FEV1%predicted values of the two groups increased,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion:Conventional treatment combined with ambroxol hydrochloride and procaterol hydrochloride in the treatment of mycoplasma pneumoniae pneumonia in children has a remarkable effect,which can effectively relieve clinical symptoms,reduce inflammatory response and improve lung function.