哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果观察

Efficacy of Piperacillin Sodium and Tazobactam Sodium in the Treatment of Acute Bronchiectasis Infection

目的:观察哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果。方法:选取2021年2月—2023年2月莱西市市立医院收治的支气管扩张急性感染患者88例为研究对象,按照随机数字表法分为对照组和观察组,各44例。对照组采用阿莫西林钠克拉维酸钾治疗,观察组采用哌拉西林钠他唑巴坦钠治疗。比较两组细菌清除率、炎性指标水平以及不良反应发生率。结果:观察组细菌清除率高于对照组,差异有统计学意义(P=0.015)。治疗前,两组白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平比较,差异无统计学意义(P>0.05);治疗后,两组WBC、CRP、PCT水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.020)。结论:哌拉西林钠他唑巴坦钠治疗支气管扩张急性感染的效果良好,病原菌清除率较高,可降低炎性指标水平,且不良反应发生率较低。

Objective:To observe the effect of piperacillin sodium and tazobactam sodium on acute bronchiectasis infection.Methods:A total of eighty-eight patients with acute infection of bronchiectasis admitted to Laixi Municipal Hospital from February 2021 to February 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with forty-four cases in each group.The control group was treated with amoxicillin sodium and clavulanate potassium,and the observation group was treated with piperacillin sodium and tazobactam sodium.The bacterial clearance rate,inflammatory indexes and the incidence of adverse reactions were compared between the two groups.Results:The bacterial clearance rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.015).Before treatment,there was no significant difference in the levels of white blood cell count(WBC),C-reactive protein(CRP)and procalcitonin(PCT)between the two groups(P>0.05);after treatment,the levels of WBC,CRP and PCT in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.020).Conclusion:Piperacillin sodium and tazobactam sodium in the treatment of acute bronchiectasis infection has a good effect,a high clearance rate of pathogenic bacteria,can reduce the level of inflammatory indicators,and the incidence of adverse reactions is low.