阿托伐他汀、依那普利分别联合缬沙坦治疗慢性肾炎的效果比较

Comparison of Efficacy of Atorvastatin and Enalapril Combined with Valsartan in the Treatment of Chronic Nephritis

目的:比较阿托伐他汀、依那普利分别联合缬沙坦治疗慢性肾炎的效果。方法:选取2022年6月—2023年6月枣庄市市中区税郭镇中心卫生院收治的慢性肾炎患者86例为研究对象,根据随机数字表法分为参照组和研究组,各43例。参照组采用依那普利联合缬沙坦治疗,研究组采用阿托伐他汀联合缬沙坦治疗。比较两组治疗效果、肾功能指标、炎性指标及不良反应发生率。结果:研究组治疗总有效率高于参照组,差异有统计学意义(P=0.013);治疗后,两组尿素氮、24 h尿蛋白和血肌酐水平均低于治疗前,研究组低于参照组,差异有统计学意义(P<0.05);治疗后,两组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白水平均低于治疗前,研究组低于参照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀联合缬沙坦治疗慢性肾炎的效果优于依那普利,可有效改善患者肾功能,降低炎性反应,且不会增加不良反应发生率。

Objective:To compare the efficacy of atorvastatin and enalapril combined with valsartan in the treatment of chronic ne⁃phritis.Methods:A total of eighty-six patients with chronic nephritis admitted to Zaozhuang Shizhong District Shuiguo Town Cen⁃tral Health Center from June 2022 to June 2023 were selected as the study objects,and were divided into the reference group and the study group according to random number table method,with forty-three cases in each group.The reference group was treated with enalapril combined with valsartan,and the study group was treated with atorvastatin combined with valsartan.The therapeutic effect,renal function index,inflammatory index and incidence of adverse reactions were compared between the two groups.Re⁃sults:The total effective rate of the study group was higher than that of the reference group,and the difference was statistically sig⁃nificant(P=0.013);after treatment,the levels of urea nitrogen,24 h urinary protein and blood creatinine in 2 groups were lower than before treatment,and the levels in the study group were lower than those in the reference group,the difference was statisti⁃cally significant(P<0.05);after treatment,the levels of tumor necrosis factor-α,interleukin-6 and C-reactive protein in 2 groups were lower than before treatment,and the study group was lower than the reference group,the difference was statistically signifi⁃cant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclu⁃sion:Atorvastatin combined with valsartan is more effective than enalapril in the treatment of chronic nephritis,which can effec⁃tively improve patients'kidney function and reduce inflammatory response without increasing the incidence of adverse reactions.