丙泊酚复合氯化琥珀胆碱静脉麻醉对无抽搐电休克患者临床指标的影响

Effect of Propofol Combined with Succinylcholine Chloride Intravenous Anesthesia on Clinical Indicators in Patients with Non-convulsive Electroshock

目的:探讨丙泊酚复合氯化琥珀胆碱静脉麻醉对无抽搐电休克患者临床指标的影响。方法:选取2020年1月—2023年10月于昆山市精神卫生中心行无抽搐电休克治疗的患者100例为研究对象,以投掷硬币法分为参照组和研究组,各50例。两组均使用阿托品麻醉,在此基础上,参照组采用丙泊酚静脉麻醉,研究组采用丙泊酚复合氯化琥珀胆碱药物静脉麻醉。比较两组治疗前及放电后1、3、5 min的血氧分压、心率以及血压水平。结果:治疗前,两组血氧分压比较,差异无统计学意义(P>0.05);放电后1、3、5 min,两组血氧分压低于治疗前,研究组高于参照组(P<0.05)。治疗前,两组心率比较,差异无统计学意义(P>0.05);放电后1、3、5 min,两组心率高于治疗前,研究组低于参照组(P<0.05)。治疗前,两组收缩压、舒张压比较,差异无统计学意义(P>0.05);放电后1、3、5 min,两组收缩压及舒张压均高于治疗前,研究组低于参照组(P<0.05)。结论:无抽搐电休克治疗期间,应用丙泊酚复合氯化琥珀胆碱静脉麻醉对精神疾病患者的临床指标的影响小于丙泊酚静脉麻醉,安全性更高。

Objective:To investigate the effect of propofol combined with succinylcholine chloride intravenous anesthesia on clini⁃cal indicators in patients with electroconvulsive shock.Methods:A total of 100 patients who underwent electroconvulsive therapy without convulsion in Kunshan Mental Health Center from January 2020 to October 2023 were selected as study subjects,and they were divided into control group and study group,with 50 patients in each group.Both groups were anesthetized with atropine,and on this basis,the control group received intravenous anesthesia with propofol,while the study group received intravenous anesthe⁃sia with propofol combined with succinylcholine chloride.The blood oxygen partial pressure,heart rate and blood pressure of 1,3,5 min before treatment and after discharge were compared between the two groups.Results:Before treatment,there was no significant difference in oxygen partial pressure between the two groups(P>0.05);at 1,3 and 5 min after discharge,the partial pressure of blood oxygen was lower in both groups than before treatment,but higher in study group than in reference group(P<0.05);there was no sig⁃nificant difference in heart rate between the two groups before treatment(P>0.05);at 1,3 and 5 min after discharge,the heart rate of two groups was higher than that before treatment,but the heart rate of study group was lower than that of reference group(P<0.05);there was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups before treat⁃ment(P>0.05).At 1,3,5 min after discharge,systolic blood pressure and diastolic blood pressure were higher in both groups than before treatment,but lower in study group than in reference group(P<0.05).Conclusion:The effect of intravenous anesthesia with propofol combined with succinylcholine chloride on clinical indicators of patients with mental disorders was less than that of intrave⁃nous anesthesia with propofol during electroconvulsive therapy.