丝状真菌转录因子调控非核糖体肽合成酶介导的次级代谢产物合成研究进展

Advance on Transcription Factors Regulating the Synthesis of Secondary Metabolites Mediated by NRPS in Filamentous Fungi

丝状真菌(Filamentous fungi)产生的次级代谢产物(Secondary Metabolites,SM)广泛应用于生物医药、生物防治及食品等领域。大多数SM的生物合成与非核糖体肽合成酶(Nonribosomal peptide synthetase,NRPS)的催化密切相关,故NRPS的表达调控对SM的生物合成至关重要。为了深入了解丝状真菌NRPS基因簇的表达调控模式,本文就通路特异性和全局性两种转录因子调控丝状真菌NRPS介导SM生成的研究进展进行了综述,以期深化对丝状真菌中转录因子调控NRPS介导的SM生成机制的认识,为丝状真菌天然产物的开发提供参考依据。

Secondary metabolites(SM)produced by filamentous fungi have been extensively applied in biomedicine,biological control,food,and other fields.The biosynthesis of most SMs is closely associated with the catalysis of nonribosome peptide synthetase(NRPS),therefore the expression regulation of NRPS is crucial for SM biosynthesis.In order to further understand the expression regulation patterns of NRPS gene clusters in filamentous fungi,herein,the research progresses on the transcription factors regulating NRPS-mediated SM production are reviewed,of which both pathwayspecific transcription factors and global transcription factors are individually descripted.The summarization is hoped to deepen the comprehension of NRPS-mediated SMs production regulated by transcription factors and provide a reference for development of natural products in filamentous fungi in the future.