铁死亡与肾纤维化相关性的研究现状

Research status of the correlation between ferroptosis and renal fibrosis

肾纤维化是所有慢性肾病共同病理表现。铁死亡与肾纤维化发病密切相关,可以影响肾纤维化的发病,其是肾纤维化发生最关键的一步。本文阐述了铁死亡和肾纤维化关系,探讨铁死亡在肾纤维化的研究进展,并进一步总结、分析、阐述针对铁死亡的有效和高靶向性的中药天然活性成分,得出通过调控铁死亡关键靶点来逆转肾纤维化,以期为其在肾纤维化疾病预防和治疗领域前景提供广阔的新方向,为临床治疗提供科学的指导和依据。

Renal fibrosis is a common pathological manifestation of all chronic kidney diseases.Ferroptosis is closely related to the pathogenesis of renal fibrosis and can influence the onset of renal fibrosis,and it is the most critical step in the development of renal fibrosis.The paper describes the relationship between ferroptosis and renal fibrosis,discusses the research progress of ferroptosis on renal fibrosis,and further summarizes,analyzes,and describes the effective and highly targeted natural active ingredients of traditional Chinese medicines against ferroptosis,and concludes that the reversal of renal fibrosis is achieved through the regulation of the key targets of ferroptosis,with a view to providing a broad new direction for its prospects in the field of renal fibrotic disease prevention and treatment;and to provide a scientific guide for clinical treatment and basis for clinical treatment.