摘要
探讨铁过载对治疗重型再生障碍性贫血(SAA)患儿异基因造血干细胞移植(allo-HSCT)疗效的影响。通过对武汉儿童医院血液科2018年1月至2022年8月间接受allo-HSCT的74例SAA患儿的临床资料进行回顾性分析,发现移植前铁过载组[血清铁蛋白(SF)>1000μg/L]患儿移植前病程更长、红细胞输注量更大、回输CD34^(+)细胞数更多,且铁过载显著延迟了移植后调节性T细胞(Treg细胞)的重建,增加了移植后出血性膀胱炎和Ⅲ~Ⅳ度急性移植物抗宿主病的发生率。然而,铁过载对患儿的总生存率和无失败生存率并无显著影响。
This study aimed to investigate the effect of iron overload on the transplant outcomes of pediatric patients with severe aplastic anemia(SAA)undergoing allogeneic hematopoietic stem cell transplantation(allo-HSCT).A retrospective analysis was conducted on the clinical data of 74 children with SAA who received allo-HSCT at the Hematology Department of Wuhan Children’s Hospital between January 2018 and August 2022.Children with iron overload(serum ferritin>1000μg/L)before transplantation had a longer disease course,received more red blood cell transfusions,and had a higher number of CD34^(+) cells infused.Moreover,iron overload significantly delayed the reconstitution of regulatory T cells after transplantation,increasing the incidence of hemorrhagic cystitis and gradeⅢ-Ⅳacute graft-versus-host disease after transplantation.However,iron overload did not significantly affect the overall survival and failure-free survival rates of the children.
作者
晏黎
熊昊
龙飞
陈智
王卓
杨李
陶芳
陈燕
宋娜
吴旻
Yan Li;Xiong Hao;Long Fei;Chen Zhi;Wang Zhuo;Yang Li;Tao Fang;Chen Yan;Song Na;WuMing(Laboratory of Pediatric Hematology,Wuhan Children's Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430016,China;Department of Hematology,Wuhan Children's Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430016,China)
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2024年第6期586-590,共5页
Chinese Journal of Hematology