注射用七叶皂苷钠治疗口腔颌面部术后肿胀的疗效

The therapeutic efficacy of sodium aescinate for injection in the treatment of postoperative swelling of the oral and maxillofacial region

目的分析口腔颌面部术后肿胀患者使用注射用七叶皂苷钠治疗的效果做出分析。方法84例口腔颌面部术后肿胀患者,通过随机抽样法分为常规组、研究组,各42例。常规组采用甘露醇治疗,研究组采用注射用七叶皂苷钠治疗。对比两组疗效、疼痛评分、肿胀程度、疼痛程度及术后感染、瘢痕发生率。结果研究组总有效率为97.62%,高于常规组的80.95%,差异性存在统计学价值(P<0.05)。研究组术后24、48、72 h疼痛评分分别为(2.71±0.36)、(4.22±0.50)、(4.31±0.40)分,均低于常规组的(3.28±0.87)、(4.84±0.85)、(5.14±0.75)分,差异性存在统计学价值(P<0.05)。常规组肿胀程度0级19例(45.24%),1级2例(4.76%),2级13例(30.95%),3级8例(19.05%);研究组肿胀程度0级29例(69.05%),1级8例(19.05%),2级5例(11.90%),3级0例。研究组肿胀程度低于常规组,差异性存在统计学价值(P<0.05)。研究组疼痛程度0级28例(66.67%),1级10例(23.81%),2级4例(9.52%),3级0例;常规组疼痛程度0级18例(42.86%),1级3例(7.14%),2级14例(33.33%),3级7例(16.67%)。研究组疼痛程度低于常规组,差异性存在统计学价值(P<0.05)。研究组术后感染、瘢痕发生率分别为2.38%、4.76%,低于常规组的19.05%、23.81%,差异性存在统计学价值(P<0.05)。结论口腔颌面部术后肿胀患者使用注射用七叶皂苷钠治疗,可以改善患者术后肿胀情况,能够降低患者疼痛程度,且术后感染发生率较低,疗效显著,临床应用价值较高。

Objective To analyze the effect of sodium aescinate for injection in the treatment of postoperative swelling of the oral and maxillofacial region.Methods 84 patients with postoperative swelling of the oral and maxillofacial region were divided into a routine group and a study group by random sampling method,with 42 cases in each group.The conventional group was treated with mannitol,and the study group was treated with sodium aescinate for injection.The efficacy,pain score,swelling degree,pain intensity,and incidence of postoperative infection and scarring were compared between the two groups.Results The total effective rate of the study group was 97.62%,which was higher than 80.95%of the conventional group,and the difference was statistically valuable(P<0.05).The pain scores of the study group were(2.71±0.36),(4.22±0.50)and(4.31±0.40)points,which were lower than(3.28±0.87),(4.84±0.85)and(5.14±0.75)points of the routine group,and the difference was statistically valuable(P<0.05).The degree of swelling in the routine group was grade 0 in 19 cases(45.24%),grade 1 in 2 cases(4.76%),grade 2 in 13 cases(30.95%)and grade 3 in 8 cases(19.05%);the degree of swelling in the study group was grade 0 in 29 cases(69.05%),grade 1 in 8 cases(19.05%),grade 2 in 5 cases(11.90%)and grade 3 in 0 cases.The degree of swelling in the study group was lower than that in the routine group,and the difference was statistically valuable(P<0.05).The pain intensity in the study group was grade 0 in 28 cases(66.67%),grade 1 in 10 cases(23.81%),grade 2 in 4 cases(9.52%),and grade 3 in 0;the pain intensity in the routine group was grade 0 in 18 cases(42.86%),grade 1 in 3 cases(7.14%),grade 2 in 14 cases(33.33%),and grade 3 in 7 cases(16.67%).The pain intensity of the study group was lower than that of the routine group,and the difference was statistically valuable(P<0.05).The incidence of postoperative infection and scarring in the study group was 2.38%and 4.76%,which were lower than 19.05%and 23.81%in the conventional group,and the difference was statistically valuable (P<0.05). Conclusion The application of sodium aescinate for injection shows significant efficacy for patients with postoperative swelling of the oral and maxillofacial region, which can improve the postoperative swelling, reduce the pain intensity of patients, and the incidence of postoperative infection is low. It has high clinical application value.