麻珠2号方联合氨茶碱片治疗阳虚型窦性心动过缓临床研究

Clinical Study on Mazhu No. 2 Prescription Combined with Aminophylline Tablets for Sinus Bradycardia of Yang Deficiency Type

目的:观察麻珠2号方联合氨茶碱治疗阳虚型窦性心动过缓的临床疗效。方法:选取58例阳虚型窦性心动过缓患者,按随机数字表法分为观察组和对照组各29例。对照组给予氨茶碱片口服,观察组在对照组基础上采取麻珠2号方治疗。疗程共2周。比较2组临床疗效、中医证候积分、24 h动态心电图(平均心率、最低心率、最高心率、总心率)及不良反应。结果:观察组总有效率96.55%,高于对照组79.31%(P<0.05)。治疗后,2组中医证候积分较治疗前降低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗后,2组平均心率、最低心率、最高心率及总心率较治疗前提高(P<0.05),且观察组平均心率、最低心率、最高心率及总心率高于对照组(P<0.05)。观察组不良反应发生率为6.90%,低于对照组27.58%(P<0.05)。结论:麻珠2号方联合氨茶碱治疗阳虚型窦性心动过缓疗效确切,可改善患者临床症状,促使24h心电图监测结果快速恢复正常,药物安全性高。

Objective:To observe the clinical effect of Mazhu No.2 Prescription combined with Aminophylline for sinus bradycardia of yang deficiency type.Methods:A total of 58 cases of patients with sinus bradycardia of yang deficiency type were selected and divided into the observation group and the control group according to the random number table method,with 29 cases in each group.The control group was treated with Aminophylline Tablets orally,and the observation group was additionally treated with Mazhu No.2 Prescription based on the treatment of the control group.The treatment course lasted for two weeks.Clinical effects,traditional Chinese medicine(TCM)syndrome scores,24-hour dynamic electrocardiogram(mean heart rate,lowest heart rate,highest heart rate,and total heart rate),and adverse reactions were compared between the two groups.Results:The total effective rate was 96.55%in the observation group,which was higher than that of 79.31%in the control group(P<0.05).After treatment,TCM syndrome scores in the two groups were reduced when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group (P<0.05). After treatment,the mean heart rate,lowest heart rate,highest heart rate,and total heart ratein the two groups were increased when compared with those before treatment (P<0.05), and the meanheart rate,lowest heart rate,highest heart rate,and total heart rate in the observation group were higherthan those in the control group (P<0.05). The incidence of adverse reactions was 6.90% in the obsertationgroup, which was lower than that of 27.58% in the control group (P<0.05). Conclusion: Mazhu No. 2Prescription combined with Aminophylline has a definite curative effect in the treatment of sinus bradycardiaof yang deficiency type, which can improve clinical symptoms of patients and promote the recovery of24-hour electrocardiogram monitoring results,with high medication safety.