中药方涂擦治疗糖尿病周围神经病变临床研究

Clinical Study on Rubbing of Chinese Herbal Prescriptions for Diabetic PeripheralNeuropathy

目的:观察中药方涂擦治疗糖尿病周围神经病变的临床疗效。方法:将102例糖尿病周围神经病变患者按随机双盲法分为西医组与中西医组各51例。西医组采用常规西药治疗,中西医组采用常规西药联合中药方涂擦治疗。比较2组治疗前后Wagner分级、多伦多临床评分系统(TCSS)评分、神经电生理指标(正中神经与腓肠神经的运动神经传导速度、感觉神经传导速度)、氧化应激指标(超氧化物歧化酶、总抗氧化能力、丙二醛),并比较2组临床疗效。结果:治疗后,中西医组Wagner分级的0级构成比为100%,高于西医组92.16%(P<0.05)。治疗后,2组TCSS各项评分及总评分均降低(P<0.05),且中西医组低于西医组(P<0.05)。治疗后,2组正中神经、腓肠神经的运动、感觉神经传导速度均增大(P<0.05),且中西医组大于西医组(P<0.05)。治疗后,2组超氧化物歧化酶水平均升高(P<0.05),且中西医组高于西医组(P<0.05);2组总抗氧化能力、丙二醛水平均降低(P<0.05),且中西医组低于西医组(P<0.05)。治疗后,中西医组总有效率94.12%,高于西医组80.39%(P<0.05)。结论:中药方涂擦治疗糖尿病周围神经病变效果显著,能够明显减轻患者的临床症状,改善神经电生理指标与氧化应激指标。

Objective:To observe the clinical effect of rubbing of Chinese herbal prescriptions on diabetic peripheral neuropathy.Methods:A total of 102 patients with diabetic peripheral neuropathy were divided into the western medicine group and the Chinese and western medicine group according to randomized double-blind method,with 51 cases in each group.The western medicine group was treated with conventional western medicine,and the Chinese and western medicine group was treated with conventional western medicine and rubbing of Chinese herbal prescriptions.The Wagner grading,scores of Toronto Clinical Scoring System(TCSS),neuroelectrophysiological indexes(motor nerve conduction velocity,sensory nerve conduction velocity of median nerve and sural nerve)and oxidative stress indexes(superoxide dismutase,total antioxidant capacity,malonaldehyde)before and after treatment as well as the clinical effects were compared between the two groups.Results:The component ratio of Wagner Grade 0 in the Chinese and western medicine group was 100%,higher than that of 92.16%in the western medicine group (P<0.05). After treatment,each score of TCSS and the total scores in the two groups weredecreased (P<0.05), and the above scores in the Chinese and western medicine group were lower thanthose in the western medicine group (P<0.05). After treatment, the movement and sensory nerveconduction velocity of median nerve and sural nerve were increased in both groups (P<0.05), and theabove indexes in the Chinese and western medicine group were higher than those in the western medicinegroup (P<0.05). After treatment,the levels of superoxide dismutase in the two groups were increased (P<0.05),and the above level in the Chinese and western medicine group was higher than that in the westernmedicine group (P<0.05);the levels of total antioxidant capacity and malondialdehyde in the two groupswere reduced (P<0.05),and the above levels in the Chinese and western medicine group were lower thanthose in the western medicine group (P<0.05). After treatment,the total effective rate was 94.12% in theChinese and western medicine group,higher than that of 80.39% in the western medicine group (P<0.05).Conclusion:Rubbing of Chinese herbal prescriptions has a significant therapeutic effect on treating diabeticperipheral neuropathy, which can significantly reduce the clinical symptoms of patients and improve theneuroelectrophysiological indexes and oxidative stress indexes.