黄芩汤加减治疗小儿湿热型泄泻临床研究

Clinical Study on Modified Huangqin Decoction for Children with Diarrhea of Damp-Heat Type

目的:观察黄芩汤加减治疗小儿湿热型泄泻的临床疗效。方法:选取96例湿热型泄泻患儿,根据治疗方式不同将其分为中药组与西药组各48例。中药组给予黄芩汤加减治疗,西药组给予蒙脱石散治疗。比较2组临床疗效及不良反应,比较2组治疗前后中医证候积分、炎症性肠病生活质量量表(IBDQ)评分、炎症因子水平、免疫功能指标水平。结果:中药组治疗总有效率95.83%,高于西药组83.33%(P<0.05)。治疗后,2组大便性状、腹胀腹痛、口干发热及乏力神倦等中医证候积分均降低(P<0.05),且中药组均低于西药组(P<0.05)。治疗后,2组肠道症状、全身症状、情感能力及社会能力等IBDQ评分均升高(P<0.05),且中药组均高于西药组(P<0.05)。治疗后,2组血清白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、超敏C-反应蛋白(hs-CRP)水平均降低(P<0.05),且中药组低于西药组(P<0.05)。治疗后,2组血清免疫球蛋白G (IgG)、免疫球蛋白M (IgM)、免疫球蛋白A (IgA)水平均升高(P<0.05),且中药组高于西药组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对湿热型泄泻患儿采用黄芩汤加减治疗能够取得良好的临床疗效,可显著改善中医症状,降低机体炎症反应,提高免疫力,且安全性好。

Objective:To observe the clinical effect of modified Huangqin Decoction on children with diarrhea of damp-heat type.Methods:A total of 96 cases of children with diarrhea of damp-heat type were selected and divided into the Chinese medicine group and the western medicine group according to different treatment methods,with 48 cases in each group.The Chinese medicine group was treated with modified Huangqin Decoction,and the western medicine group was treated with oral administration of probiotics.Clinical effects and adverse reactions were compared between the two groups.Traditional Chinese medicine syndrome scores,the scores of the Inflammatory Bowel Disease Questionnaire(IBDQ),and the levels of inflammatory factors and immune function indicators were compared between the two groups before and after treatment.Results:The total effective rate was 95.83%in the Chinese medicine group,higher than that of 83.33%in the western medicine group(P<0.05).After treatment,traditional Chinese medicine syndrome scores of stool features,abdominal distension and pain,dry mouth and fever,and lack of strength and lassitude of spirit in the two groups were decreased(P<0.05),and the scores in the Chinese medicine group were lower than those in the western medicine group (P<0.05). After treatment,IBDQ scores of intestinal symptoms, systemic symptoms, emotional domain, and social domain in thetwo groups were increased (P<0.05), and the scores in the Chinese medicine group were higher thanthose in the western medicine group (P<0.05). After treatment, the levels of serum interleukin-6 (IL-6)and tumor necrosis factor-α (TNF-α),high-sensitivity C-reactive protein (hs-CRP) in the two groups weredeclined (P<0.05), and the levels in the Chinese medicine group were lower than those in the westernmedicine group (P<0.05). After treatment, the levels of serum immunoglobulin G (IgG), immunoglobulinM (IgM), and immunoglobulin A (IgA) in the two groups were increased (P<0.05), and the levels in theChinese medicine group were higher than those in the western medicine group (P<0.05). There was nosignificant difference being found in the incidence of adverse reactions between the two groups (P>0.05).Conclusion: Modified Huangqin Decoction can achieve good clinical effects in the treatment of childrenwith diarrhea of damp-heat type,which can significantly improve traditional Chinese medicine symptoms,reduce body inflammatory reactions,and enhance immunity,with good safety.