蛋白激酶CK2调控肿瘤相关信号通路功能的研究进展

Research progress of protein kinase CK2 in regulating the function of tumor-related signaling pathways

蛋白激酶CK2是一种高度保守的、普遍存在的蛋白激酶,具有磷酸化多种蛋白底物的功能,并参与多种信号通路的调控过程。CK2的表达失衡会导致多种信号通路的失调,与肿瘤的发生、发展密切相关。该文综述了CK2的组成、结构及其在肿瘤相关的重要信号通路中的调控作用,以期为进一步探究以CK2为靶标的肿瘤治疗策略提供依据。

Protein kinase CK2 is a highly conserved and ubiquitous protein kinase which phosphorylates a variety of protein substrates,and is involved in the regulation of several signaling pathways.Abnormal CK2 expression can lead to dysregulation of various signaling pathways,which is closely related to tumorigenesis and progression.This review summarizes the composition,structure and regulatory role of CK2 in important tumor-related signaling pathways and provides foundation to further explore CK2-targeted therapeutic strategies in cancer.