性激素在干燥综合征中的研究进展

Research progress of sex hormones in Sjogren's syndrome

性激素是由性腺和肾上腺产生或由其他物质转化而来的类固醇激素。干燥综合征(Sj?gren's syndrome,SS)是一种由淋巴细胞介导的慢性进行性系统性自身免疫病,主要累及外分泌腺,其病因复杂,发病机制尚未完全阐明。女性发病率比男性高,这提示性激素和SS发生、发展之间存在关联。该文分析雌激素、雄激素和催乳素对SS的作用机制的影响,为深入了解SS的发病机制及探究其治疗方法提供参考。

Sex hormones are steroid hormones secreted by gonads and adrenal glands or converted from other substances.Sjogren's syndrome(SS)is a chronic progressive systemic autoimmune disease mediated by lymphocytes,mainly affecting exocrine glands.Due to the complex etiology,its pathogenesis has not been fully elucidated.The fact that the incidence of SS is higher in women than in men suggests a relationship between sex hormones and the development of SS.This review discusses the mechanism and influence of estrogen,androgen,and prolactin on SS to provide reference to understand the pathogenesis of SS and explore the therapeutic strategies.