颈部不明原发灶转移癌的诊断与治疗进展

Clinical analysis on cervical metastatic carcinoma from unknown primary

颈部不明原发灶转移癌(CMCUP)通常是指组织细胞学、病理学证实为颈部淋巴结转移性恶性肿瘤,但经过系统的病史采集、体格检查、内镜及影像学等检查,仍然无法明确原发病灶的颈部转移性恶性肿瘤。虽然随着内镜及影像学等检查技术的发展,近年来CMCUP的检出逐年增高,但仍有部分患者无法通过已知的检查手段确诊原发灶。对于CMCUP患者的诊断治疗,需要正确识别临床表现,应利用最少侵入性的途径来实现诊断和治疗,避免不恰当的诊断方式。规范化治疗的现状不容乐观,亟需重视CMCUP的规范诊治。本文将聚焦CMCUP临床关注的重点诊疗问题及最新进展,为CMCUP的临床规范化诊治提供参考。

Cervical metastatic carcinoma from unknown primary lesion(CMCUP)usually refers to a malignant tumor confirmed by histological and pathological examination as cervical lymph node metastasis.However,after systematic medical history collection,physical examination,endoscopy,and imaging examinations,it is still unclear whether the primary lesion is cervical metastatic malignant tumor.Although with the development of examination techniques such as endoscopy and imaging,the detection of unknown primary lesions has been increasing year by year in recent years,there are still some cases where the primary lesion cannot be diagnosed through known examination methods.For the diagnosis and treatment of patients with unknown primary metastatic cancer in the neck,it is necessary to correctly identify clinical manifestations and use the least invasive approach to achieve diagnosis and treatment,avoiding inappropriate diagnostic methods.The current situation of standardized treatment is not optimistic,and there is an urgent need to pay attention to the standardized diagnosis and treatment of cervical metastatic cancer from unknown primary lesions.This article will focus on the key diagnostic and treatment issues and the latest progress of CMCUP clinical attention,providing reference for the standardized clinical diagnosis and treatment of cervical metastatic cancer from unknown primary lesions.