10-羟基-2-癸烯酸功能与合成方法研究进展

Advances in the Function and Synthesis Methods of 10-Hydroxy-2-decenoic Acid

蜂王浆是年轻工蜂上颚腺的浓稠的乳白色分泌物,作为一种天然的蜂产品,被广泛应用于食品和保健品等各个领域。10-羟基-2-癸烯酸(10-hydroxy-2-decenoic Acid,10-HDA)是蜂王浆中所特有的一种中链不饱和脂肪酸,具有抗菌、抗炎、抗肿瘤、降低血糖、血脂和抗辐射等多种活性功能。利用物理吸附或有机溶剂处理,可以在蜂王浆中有效提取出10-HDA成分,此外,还可以利用8-羟基辛醛、1,8-辛二醇等物质,通过各种化学反应合成10-HDA。近年来,也出现了使用微生物生产10-HDA的方式,这种方法因其成本低、污染小的特性,迅速成为了研究热点。通过归纳总结10-HDA的理化性质、生理活性及生产10-HDA的各种方法,简要阐述了不同的生产方式的优缺点,并对其中存在的问题进行讨论和展望,旨在为10-HDA的深入研究提供借鉴与参考。

Royal jelly is a thick,milky white secretion from the palatine glands of young worker bees.As a natural bee product,it finds wide application in various fields,including food and health care products.One of the unique components of royal jelly is 10-hydroxy-2-decenoic acid(10-HDA),a medium-chain unsaturated fatty acid.10-HDA possesses several active functions,such as antibacterial,anti-inflammatory,anti-tumor,blood sugar regulation,blood lipid control,and antiradiation properties.The extraction of 10-HDA from royal jelly can be efficiently achieved through physical adsorption or organic solvent treatment.Additionally,10-HDA can be synthesized by various chemical reactions using substances such as 8-hydroxyoctanal and 1,8-octanediol.In recent years,utilizing microorganisms for 10-HDA production has gained significant attention owing to its low cost and low pollution characteristics.This method has become a research hotspot.This article provides a summary of the physicochemical properties,physiological active functions,and different methods of 10-HDA production.Furthermore,it briefly discusses the advantages and disadvantages of these production methods and highlights the existing problems and prospects to offer valuable reference and information for further in-depth research on 10-HDA.