生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用

The role of circadian clock-controlled mitochondrial dynamics in nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是一种与代谢异常密切相关的疾病,是目前最常见的慢性肝病之一。线粒体是高度动态的细胞器,参与肝脏中的多种代谢和生物能量通路,通过线粒体动力学对环境变化做出高度动态反应。生物钟能够调控线粒体动力学,使其表现出节律性变化。当昼夜节律紊乱时,线粒体动力学失去节律性,使得线粒体不能对不同环境中不断变化的能量需求做出反应,导致NAFLD的发生发展。本文总结了生物钟调控的线粒体动力学在NAFLD病因学中的重要作用。

Nonalcoholic fatty liver disease(NAFLD)is a disease closely associated with metabolic abnormalities and is currently one of the most common chronic liver diseases.Mitochondria are highly dynamic organelles involved in a variety of metabolic and bioenergetic pathways in the liver,and they respond to environmental changes in a highly dynamic manner through mitochondrial dynamics.The circadian clock is able to modulate mitochondrial dynamics,making it exhibit rhythmic changes.In case of circadian rhythm disorders,mitochondrial dynamics loses rhythmicity,and mitochondria are unable to respond to changing energy demands in different environments,leading to the development and progression of NAFLD.This article summarizes the important role of circadian clock-controlled mitochondrial dynamics in the etiology of NAFLD.