铁死亡在肝缺血再灌注损伤中的作用

Role of ferroptosis in hepatic ischemia-reperfusion injury

铁死亡是一种新型调节性细胞死亡,主要由于各种诱导剂导致细胞内铁稳态的改变,促进铁离子依赖性的脂质过氧化反应的发生,由此引发了有毒的脂质过氧化物大量堆积,最终导致细胞死亡。肝缺血再灌注损伤是肝脏手术后常见且严重的并发症,主要机制包括无氧呼吸、线粒体损伤、氧化应激反应、炎症反应、钙超载、微循环功能障碍等。本文对铁死亡和肝缺血再灌注损伤的概念和机制进行介绍,并总结了与二者有关的部分治疗策略,为探索肝缺血再灌注损伤新的治疗手段提供参考。

Ferroptosis is a new type of regulatory cell death and is mainly caused by changes in intracellular iron homeostasis due to various inducers,which promotes the occurrence of iron ion-dependent lipid peroxidation,thereby leading to the accumulation of toxic lipid peroxides and finally resulting in cell death.Hepatic ischemia-reperfusion injury is a common and serious complication after liver surgery,with the main mechanisms of anaerobic respiration,mitochondrial injury,oxidative stress response,inflammatory response,calcium overload,and microcirculation dysfunction.This article introduces the concepts and mechanisms of ferroptosis and hepatic ischemia-reperfusion injury and summarizes some related treatment strategies,so as to provide a reference for exploring new treatment methods for hepatic ischemia-reperfusion injury.