单绒毛膜双胎之一胎死宫内存活胎脑损伤的研究进展

Research Progress on the Brain Injury in Survivors Following Single Intrauterine Fetal Death in Monochorionic Twins

随着促排卵技术和辅助生殖技术的发展,多胎妊娠率逐年升高。双胎之一胎死宫内(single intrauterine fetal death,sIUFD)是单绒毛膜双胎妊娠中晚期的严重并发症。一胎死亡后,存活胎神经系统受损是影响新生儿及婴幼儿远期预后的重要因素,严重影响人口质量。研究存活胎神经系统受损的机制及有效地监测存活胎可能发生的脑损伤,对预防严重脑损伤并发症至关重要,也是妊娠期管理和分娩时机选择的重要依据。通过识别sIUFD存活胎神经损伤的相关危险因素,采取合适的监测手段和宫内治疗,制定相应的分娩方案,以减少存活胎不良神经结局的发生。

With the development of ovulation promotion and assisted reproductive technology,the rate of multiple pregnancies is increasing year by year.Single intrauterine fetal death(sIUFD) in twins is a serious complication of monochorionic twins in middle and late stages.After single intrauterine death,neurological impairment of the surviving fetus is an important factor affecting the long-term prognosis of newborns and infants,which seriously affects the quality of the population.The study of the mechanisms of neurological damage and effective monitoring of possible brain damage in surviving fetus are essential for the prevention of severe brain injury complications and important basis for causing the management of pregnancy and the timing of delivery.By identifying the risk factors associated with neurological damage in surviving fetuses with sIUFD,adopting appropriate monitoring and intrauterine treatment,and developing appropriate delivery plans,we can reduce the incidence of poor neurological outcomes in surviving fetuses.