催产素预防产后出血的研究进展

Research Progress of Oxytocin in Preventing Postpartum Hemorrhage

产后出血是常见的产科并发症,是导致全球孕产妇死亡的首要原因,子宫收缩乏力是导致产后出血的主要原因。催产素及卡贝催产素等子宫收缩剂是预防和治疗子宫收缩乏力的一线药物,催产素作为预防产后出血的首选药物和世界卫生组织推荐的一线子宫收缩剂,其在不同分娩方式中的用药途径、给药时机、剂量和给药速率等方案尚未达成一致。其中多胎妊娠、肥胖等产后出血高危人群中催产素的使用方案与低危人群不同,现有研究的热点是在产后出血高危人群中,如何以最低剂量达到最佳的预防效果,减少药物的不良反应。综述催产素预防产后出血及其给药方案,总结催产素在不同分娩方式中的应用并对未来的研究方向作出展望。

Postpartum hemorrhage is a common obstetric complication and the leading cause of maternal death worldwide,and weak uterine contraction is the main cause of postpartum hemorrhage.Uterine contractions such as oxytocin and carbe oxytocin are the first-line drugs for the prevention and treatment of weak uterine contraction.Oxytocin,as the first-line uterine contractions recommended by WHO for the prevention of postpartum hemorrhage,has not yet reached a consensus on the medication route,administration time,dosage and rate in different delivery methods.Among them,the use of oxytocin in high-risk groups of postpartum hemorrhage such as multiple pregnancies and obesity is different from that in low-risk groups.Current research focuses on how to achieve the best preventive effect with the lowest dose and reduce the adverse effects of the drugs in high-risk groups of postpartum hemorrhage.This paper reviews the prevention of postpartum hemorrhage with oxytocin and its administration plan.The application of oxytocin in different delivery modes was summarized and the future research direction was prospected.