干细胞治疗早发性卵巢功能不全的现状及未来展望

Progress and future prospects of stem cell therapy for premature ovarian insufficiency

早发性卵巢功能不全(POI)是一种女性卵巢功能障碍的疾病,发病原因复杂,近年来发病率呈上升趋势。POI是导致女性不孕的主要因素之一,而目前激素替代治疗并不能有效恢复患者生殖能力。干细胞具有自我更新、损伤修复和多向分化等生物学功能,是治疗POI的新思路,然而目前其临床应用研究的结果却仍不理想。本文从干细胞治疗POI的细胞种类、作用机制、研究现状和未来潜力进行总结分析,并对影响干细胞治疗POI的疗效因素和提高其疗效的方法进行讨论分析,为更好地开展干细胞治疗POI的临床研究提供参考。

Premature ovarian insufficiency(POI)is a disease of female ovarian dysfunction with complex etiology,and its incidence has shown an upward trend in recent years.POI is one of the main factors leading to female infertility,and current hormone replacement therapy cannot effectively restore the patient's reproductive ability.Stem cells have biological functions such as self-renewal,damage repair and multi-directional differentiation,which is a new approach to treating POI.However,the results of clinical application research are still unsatisfactory.This article discusses and analyzes the potential and mechanism of stem cells in the treatment of POI and its clinical research progress.It also summarizes the factors that affect the efficacy of stem cell therapy and the methods to improve its effectiveness,providing a reference for further research on stem cell therapy for POI.