预防性应用不同剂量羟考酮对胸腔镜手术患者术后疼痛的影响

Effect of preventive application of oxycodone at varying doses on the postoperative pain of patients undergoing thoracoscopic surgery

目的 观察预防应用0.1 mg/kg和0.15 mg/kg不同剂量羟考酮对胸腔镜手术患者术后疼痛的影响。方法 选取2022年1~7月接受胸腔镜手术患者80例,随机分为观察组和对照组,每组40例。2组患者均在手术结束前30 min进行预防性镇痛,对照组给予羟考酮0.1 mg/kg静脉注射,观察组羟考酮0.15 mg/kg进行静脉注射。记录2组患者术后1 h、术后6 h、术后12 h和术后24 h的静态疼痛评分(numerical rating scale, NRS)及术后24 h的不良反应发生情况,比较2组胸腔镜手术患者各时间段NRS评分及不良反应发生率。结果 本研究共纳入80例患者,随机分为对照组和观察组,2组患者的年龄、性别比、手术操作时间及出血量等一般情况差异无统计学意义(P>0.05);观察组与对照组患者在入院时相关生化指标方面的差异比较无统计学意义(P>0.05);观察组患者术后1 h和6 h的NRS评分均低于对照组(P<0.05),术后12 h和术后24 h 2组患者NRS评分差异无统计学意义(P>0.05);2组患者不良反应发生率及觉醒时间均差异无统计学意义(P>0.05)。结论 在胸腔镜手术患者中预防性应用0.15 mg/kg的盐酸羟考酮可以缓解术后疼痛,且不增加患者不良反应。

Objective To observe the effect of oxycodone at 0.1mg/kg versus 0.15mg/kg on the postoperative pain of patients undergoing thoracoscopic surgery.Methods A total of 80 patients undergoing thoracoscopic surgery from January 2022 to July 2022 were randomly allocated to the observation group(n=40)and the control group(n=40).Patients in both groups were given preventive analgesia 30min before the end of the surgery by intravenous administration of oxycodone at 0.1 mg/kg(control group)and 0.15mg/kg(observation group).The Numerical Rating Scale(NRS)scores at 1,6,12 and 24h postoperatively,and the adverse events at 24 h postoperatively were recorded and compared between groups.Results his study included a total of 80 patients who were randomly divided into a control group and an observation group.There was no statistically significant difference in age,gender,and other general information between the two groups(P>0.05);The difference in relevant biochemical indicators between the observation group and the control group at admission was not statistically significant(P>0.05);The NRS scores at 1h and 6h postoperatively were significantly lower in patients of the observation group than those of control group(P<0.05),which,at 12h and 24h postoperatively were comparable between groups(P>0.05).There were no significant differences in the incidence of adverse events and awaking time between groups(P>0.05).Conclusion A preventive application of oxycodone at 0.15mg/kg effectively alleviates postoperative pain of patients undergoing thoracoscopic surgery without increasing the incidence of adverse events.