雾化吸入多肽抗菌液结合居家管理对首发脑卒中患者吸入性肺炎发生率的影响

The impact of nebulized inhalation of Bairun peptide antibacterial solution combined with home management in preventing the incidence of aspiration pneumonia in first-episode stroke patients

目的分析首发性脑卒中患者采用雾化吸入多肽抗菌液联合居家管理对预防吸入性肺炎发生的价值。方法选取2020年1月至2023年1月收治首发脑卒中患者88例,随机分为2组,每组44例,对照组患者接受常规居家管理,使用等渗0.9%氯化钠溶液进行干预,观察组患者开展雾化吸入多肽抗菌液联合居家管理,比较2组患者吸入性肺炎发生情况、口腔菌落计数、口腔情况、运动功能与生活自理能力、生活质量。结果观察组患者吸入性肺炎发生率9.09%,低于对照组27.27%(P<0.05),干预2周观察组口腔菌落计数低于对照组(P<0.05);干预3个月后观察组患者Barthel指数、Fugl-Meyer评分高于对照组(P<0.05);干预3个月后观察组SF-36评分优于对照组(P<0.05)。结论脑卒中首发患者在居家管理中雾化吸入多肽抗菌液,能够有效抑制口腔菌落数,降低患者吸入性肺炎发生风险,并对提高患者生活自理能力、运动功能康复与生活质量具有积极作用。

Objective To analyze the value of nebulized inhalation of Bairun peptide antibacterial solution combined with home management in preventing the occurrence of aspiration pneumonia in first-episode stroke patients.Methods This study included 88 first-episode stroke patients admitted to our hospital from January 2020 to January 2023 were enrolled and grouped in a 1∶1 using a random number table method.All patients were managed by home management of 0.9%saline,those in the observation group were additionally given nebulized inhalation of Bairun peptide antibacterial solution.The incidence of aspiration pneumonia,oral bacterial count,and oral condition,sports function,self-care ability,and quality of life of the two groups were compared.Results The incidence of aspiration pneumonia in the observation group was significantly lower than that in the control group(9.09%vs 27.27%,P<0.05).After 2 weeks of intervention,the oral bacterial count in the observation group was significantly lower than that in the control group(P<0.05).After 3 months of intervention,the Barthel index and Fugl-Meyer Assessment(FMA)score of the observation group were significantly higher than those of the control group(P<0.05).After 3 months of intervention,the 36-item Short-Form Health Survey(SF-36)score in the observation group was better than that in the control group(P<0.05).Conclusion For first-episode stroke patients,the use of nebulized inhalation of Bairun peptide antibacterial solution combined with home management can effectively suppress oral bacterial count,reduce the risk of aspiration pneumonia,and it has a positive effect on improving patients’self-care ability.It has a positive effect on the rehabilitation of motor function and the improvement of quality of life.