奥氮平联合脑心通胶囊治疗精神分裂症的效果及对血清α-突触核蛋白和褪黑素水平的作用

Efficacy of Olanzapine Combined with Naoxintong Capsules in the Treatment of Schizophrenia and Its Effects on Serumα-Synuclein and Melatonin Levels

目的:探究奥氮平联合脑心通胶囊治疗精神分裂症的疗效及对血清α-突触核蛋白和褪黑素水平的影响。方法:选取2021年3月至2023年5月该院收治的精神分裂症患者124例,采用随机数字表法分为对照组和观察组,每组62例。对照组患者接受奥氮平治疗,观察组患者在对照组的基础上加用脑心通胶囊治疗,两组患者均连续治疗8周。比较两组患者的临床疗效、精神状态、生活质量、认知功能、糖代谢、血清α-突触核蛋白和褪黑素水平。结果:观察组患者的总有效率明显高于对照组[85.48%(53/62)vs.69.35%(43/62)],差异有统计学意义(P<0.05)。治疗后,观察组患者的阳性症状、阴性症状、精神病理表现以及阳性和阴性症状量表总分明显低于对照组,心理社会评分、症状和副作用评分、运动和精力评分低于对照组,神经心理状态量表评分明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗后的空腹血糖和餐后2 h血糖水平较对照组更低,α-突触核蛋白和褪黑素水平较对照组更高,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为4.84%(3/62)、6.45%(4/62),差异无统计学意义(P>0.05)。结论:奥氮平联合脑心通胶囊治疗精神分裂症患者能显著提高疗效,恢复患者精神状态、生活质量、认知功能和糖代谢水平,提高血清α-突触核蛋白和褪黑素水平,且不良反应小。

OBJECTIVE:To probe into the efficacy of olanzapine combined with Naoxintong capsules in the treatment of schizophrenia and its effects on serumα-synuclein and melatonin levels.METHODS:Totally 124 patients with schizophrenia admitted into the hospital from Mar.2021 to May 2023 were extracted to be divided into the control group and observation group via the random number table method,with 62 cases in each group.The control group received olanzapine as their treatment,while the observation group was given Naoxintong capsules on the basis of the control group for a duration of 8 weeks.The clinical efficacy,state of mind,quality of life,function of cognition,metabolism of glucose,serumα-synuclein and melatonin levels of two groups were compared.RESULTS:The total effective rate of the observation group was significantly higher than that of the control group[85.48%(53/62)vs.69.35%(43/62)],the difference was statistically significant(P<0.05).After treatment,the positive symptoms,negative symptoms,psychopathological manifestations and the total scores of positive and negative symptom scales in the observation group were significantly lower than those in the control group,the psychosocial scores,symptom and side effect scores,exercise and energy scores were lower than those in the control group,and the neuropsychological status scale scores were significantly higher than those in the control group,with statistically significant differences(P<0.05).The levels of fasting blood glucose and 2 h postprandial blood glucose after treatment in the observation group were lower than those in control group,and theα-synuclein and melatonin levels were higher than those in control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in observation group and control group was respectively 4.84%(3/62)and 6.45%(4/62),with no statistically significant difference(P>0.05).CONCLUSIONS:Olanzapine combined with Naoxintong capsules can significantly increase the efficacy of patients with schizophrenia,restore state of mind,quality of life,function of cognition and metabolism of glucose,and improve serumα-synapse protein and melatonin levels,with few adverse drug reactions.