中医眼科古籍中内障眼病方剂遣方用药规律研究

Study on the Medication Rules of the Prescriptions for Internal Ophthalmology in Ancient Classics of Ophthalmology

目的:分析中医眼科古籍中治疗内障眼病方剂的遣方用药规律。方法:从7部历代主要中医眼科古籍中筛选出治疗内障眼病的方剂并建立数据库,导入中医传承计算平台(V3.0),运用频次统计分析、四气五味分布统计、基于关联规则的组方规律分析及聚类分析等数据挖掘方法,探索古籍中治疗内障眼病的组方用药规律和辨治经验。结果:共收集322首方剂,涉及用药187味,总使用频次2867次,频率≥40次的单味药有22味,药类以补虚药、清热药、解表药为主,药味多甘味,其次为苦味、辛味,归经主要为肝经,四气统计以寒性药最多,温性药次之,统计出核心药物组合48组,聚类分析得到核心处方7个。结论:本研究充分挖掘了主要中医眼科古籍中治疗内障眼病的遣方用药规律,对今后的临床用药具有参考价值。

Objective:To analyze the medication rules of the prescriptions for internal ophthalmology in ancient classics of ophthalmology.Methods:The prescriptions for the treatment of internal ophthalmology were screened from seven ancient classics of TCM ophthalmology to establish the database,which was imported into traditional Chinese medicine inheritance computing platform(V3.0),the methods of data mining such as the statistical analysis of the frequency,the distribution of four natures and five flavors,the analysis of the medication rule based on association rules and cluster analysis were applied to explore the medication rules of the prescriptions and the experience of differentiating and treating the disease in the ancient books.Results:The study has gathered 322 prescriptions,involving 187 herbs with total frequency 2867 times,22 single herbs with the frequency of greater than 40 times,the herbs contained the ones of tonifying,clearing heat,relieving the exterior mainly,mostly belonging to sweet,bitter and pungent the next,entering the meridian of liver,mostly the cold-nature,warm-nature drugs the next,48 core drug combinations were obtained by statistical analysis,and seven core prescriptions were gained through cluster analysis.Conclusion:The study has fully unearthed the medication rules of the prescription for the treatment of internal ophthalmology in the ancient classics of TCM ophthalmology,which provides reference value for the clinical application of the medicine in the future.