脂质代谢在乳腺癌进展过程中的重要作用与机制

Important role and mechanism of lipid metabolism in breast cancer progression

乳腺癌是起源于乳腺上皮组织的恶性肿瘤,其发病率呈逐年上升趋势。脂质代谢水平和调控作用在肿瘤细胞的增殖、迁移、侵袭、转移和产生耐药性的过程中发挥重要作用。本文从脂质代谢成分(包括脂肪酸、三酰甘油和胆固醇)、脂质代谢信号通路、脂质代谢调控基因3个方面,综述脂质代谢在乳腺癌进展过程中的作用与机制,展望靶向脂质代谢治疗的潜在临床价值,为制定有效的治疗策略和开发代谢靶向药物提供理论参考。

Breast cancer is a malignant tumor originating from breast epithelial tissue,and its incidence rate is increasing year by year.Studies have shown that the level and regulation of lipid metabolism play an important role in the tumor cell proliferation,migration,invasion,metastasis,and development of drug resistance.This paper reviews the role and mechanism of lipid metabolism in the breast cancer progression from three aspects:lipid metabolism components(fatty acids,triglycerides and cholesterol),lipid metabolism signaling pathway,and regulatory genes of lipid metabolism,offers insights into the potential clinical value of targeted lipid metabolism therapy,and provides theoretical references for formulating effective treatment strategies and developing metabolism-targeted drugs.