消肿汤治疗混合痔患者术后并发症的临床效果

Clinical efficacy of Xiaozhong decoction in treatment of postoperative complications of patients with mixed hemorrhoids

目的观察消肿汤治疗混合痔患者术后并发症的临床效果。方法选取2023年2月至2024年1月岷县中医院收治的120例混合痔患者进行随机对照试验。采用随机数字表法将其分为对照组和观察组,各60例。对照组男31例,女29例,年龄(43.15±13.19)岁,病程(3.70±1.95)年,体质量指数(22.70±2.25)kg/m2。观察组男28例,女32例,年龄(42.68±14.80)岁,病程(3.90±2.36)年,体质量指数(22.91±2.13)kg/m2。两组术后均常规处理;对照组患者用高锰酸钾熏洗治疗,观察组患者用消肿汤熏洗治疗;5 d 1个疗程,两组均治疗2个疗程。治疗后,比较两组总有效率。记录两组患者术后第1、3、7、11天各项临床症状积分及治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平。采用t检验、χ^(2)检验。结果对照组总有效率为75.0%(45/60),观察组为91.7%(55/60),差异有统计学意义(P<0.05)。术后第3、7、11天,观察组疼痛、创面渗液、肛门坠胀评分均低于对照组[术后第3天:(4.93±1.07)分比(6.13±1.28)分、(1.85±0.40)分比(2.07±0.68)分、(2.02±0.75)分比(2.35±0.71)分;术后第7天:(3.53±1.11)分比(4.13±0.93)分、(1.47±0.54)分比(1.87±0.85)分、(1.53±0.50)分比(1.87±0.72)分;术后第11天:(1.62±1.11)分比(2.28±1.51)分、(0.75±0.79)分比(1.21±0.72)分、(0.63±0.58)分比(0.98±0.83)分],差异均有统计学意义(均P<0.05)。治疗后,观察组TNF-α、IL-1β、IL-6水平均低于对照组[(2.75±1.01)ng/L比(5.25±1.87)ng/L、(5.75±2.00)ng/L比(9.78±2.82)ng/L、(8.14±2.14)ng/L比(12.68±4.13)ng/L],差异均有统计学意义(均P<0.05)。结论采用消肿汤治疗混合痔患者术后并发症效果确切,值得推广应用。

Objective To observe the clinical effect of Xiaozhong decoction in the treatment of postoperative complications of patients with mixed hemorrhoids.Methods One hundred and twenty patients with mixed hemorrhoids treated at Minxian Hospital of Traditional Chinese Medicine from February 2023 to January 2024 were selected for the randomized controlled trial.The patients were divided into a control group and an observation group by the random number table method,with 60 cases in each group.There were 31 males and 29 females in the control group;they were(43.15±13.19)years old;their disease course was(3.70±1.95)years;their body mass index was(22.70±2.25)kg/m2.There were 28 males and 32 females in the observation group;they were(42.68±14.80)years old;their disease course was(3.90±2.36)years;their body mass index was(22.91±2.13)kg/m2.Both groups received routine postoperative treatment.The control group were treated with potassium permanganate fumigation,and the observation group with Xiaozhong decoction fumigation.Five days were one treatment course;both groups were treated two courses.After the treatment,the total effective rates were compared between the two groups.The scores of clinical symptoms day 1,3,7,and 11 after the operation and the levels of tumor necrosis factorα(TNFα),interleukin-1β(IL-1β),and interleukin-6(IL-6)before and after the treatment in both groups were recorded.t andχ^(2) tests were applied.Results The total effective rate in the control group was 75.0%(45/60),and that in the observation group was 91.7%(55/60),with a statistical difference(P<0.05).The scores of pain,wound exudate,and anal prolapse day 3,7,and 11 after the operation in the observation group were lower than those in the control group[day 3 after the operation:(4.93±1.07)vs.(6.13±1.28),(1.85±0.40)vs.(2.07±0.68),and(2.02±0.75)vs.(2.35±0.71);day 7 after the operation:(3.53±1.11)vs.(4.13±0.93),(1.47±0.54)vs.(1.87±0.85),and(1.53±0.50)vs.(1.87±0.72);day 11 after the operation:(1.62±1.11)vs.(2.28±1.51),(0.75±0.79)vs.(1.21±0.72),and(0.63±0.58)vs.(0.98±0.83)],with statistical differences(all P<0.05).After the treatment,the levels of TNF-α,IL-1β,and IL-6 in the observation group were lower than those in the control group[(2.75±1.01)ng/L vs.(5.25±1.87)ng/L,(5.75±2.00)ng/L vs.(9.78±2.82)ng/L,and(8.14±2.14)ng/L vs.(12.68±4.13)ng/L],with statistical differences(all P<0.05).Conclusion Xiaozhong decoction in the treatment of postoperative complications of patients with mixed hemorrhoids is effective,so it is worthy of promotion.