下肢动脉硬化闭塞症的发病机制及中西医治疗进展

Pathogenesis of Arteriosclerosis Obliterans and Progress in Traditional Chinese and Western Medicine Treatment

下肢动脉硬化闭塞症(ASO)是一种由下肢动脉粥样硬化斑块形成引起下肢动脉狭窄、闭塞,进而导致肢体慢性缺血的疾病,其特征主要包括下肢皮肤温度降低、麻木、疼痛、间歇性跛行、皮肤溃疡或坏疽等。ASO的发病机制目前尚未明确,主要可能与血管内膜损伤、脂质代谢紊乱、动脉分叉处血流动力学改变等机制相关。治疗上,西医提倡轻症药物治疗,重症以手术或血管腔内治疗;中医采用内治与外治并用,以提高疗效、降低截肢率及复发率。未来,深入研究ASO的发病机制将有助于寻找更有效的ASO临床治疗方法。

Arteriosclerosis obliterans(ASO)of lower extremities is a disease caused by the formation of atherosclerotic plaques of lower limbs,which leads to the stenosis and occlusion of lower limb arteries,and then leads to chronic ischemia of the limbs.Its characteristics mainly include lower limb skin temperature,numbness,pain,intermittent claudication,skin ulcer or gangrene.The pathogenesis of ASO is currently unclear and may be mainly related to mechanisms such as vascular intimal injury,lipid metabolism disorders,and hemodynamic changes at arterial bifurcation.In terms of treatment,western medicine advocates medication for mild cases and surgery or endovascular treatment for severe cases;traditional Chinese medicine uses a combination of internal and external treatments to improve efficacy,reduce amputation and recurrence rates.In the future,in-depth research on the pathogenesis of ASO will help to find more effective clinical treatment methods for ASO.