注射用艾普拉唑钠治疗消化性溃疡出血的临床疗效及对患者安全性的影响

Clinical efficacy and safety of ilprazole sodium for injection in the treatment of peptic ulcer bleeding

目的探究注射用艾普拉唑钠治疗消化性溃疡出血的临床疗效及对患者安全性的影响。方法选取2021年1—12月宜春市人民医院接诊的104例消化性胃溃疡出血患者作为研究对象,采用随机抽签法分为对照组与观察组,每组52例。两组均进行常规对症治疗,在此基础上,对照组辅以奥美拉唑治疗,观察组辅以注射用艾普拉唑钠治疗。比较两组临床疗效、72h止血有效率及再出血率、实验室相关指标、病情恢复情况及用药安全性。结果用药后,两组72h止血有效率比较差异无统计学意义;观察组治疗总有效率高于对照组,再出血率低于对照组,差异有统计学意义(P<0.05)。用药后,两组血清白细胞介素-6(IL-6)、胃泌素(GAS)水平均低于用药前,表皮生长因子(EGF)、血管内皮生长因子(VEGF)水平均高于用药前,且观察组IL-6、GAS水平均低于对照组,EGF、VEGF水平均高于对照组,差异有统计学意义(P<0.05)。用药1个月后,观察组止血时间、胃肠道症状消失时间均短于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论注射用艾普拉唑钠治疗消化性溃疡出血患者,且安全可靠,有利于促进病情恢复,值得临床推广应用。

Objective To explore the clinical efficacy and safety of ilprazole sodium for injection in the treatment of peptic ulcer bleeding.Methods 104 patients with peptic ulcer hemorrhage admitted to Yichun People's Hospital from January 2021 to December 2021 were selected as the study subjects,and they divided into the control group and the observation group by random drawing method,with 52 cases in each group.Both groups were treated with routine symptomatic treatment,on this basis,the control group was treated with omeprazole,and the observation group was treated with ilaprazole sodium for injection.The clinical efficacy,72 h hemostasis efficiency and rebleeding rate,laboratory related indicators,dis-ease recovery and medication safety were compared between the two groups.Results There was no significant difference in hemostatic efficiency between the two groups at 72 h after treatment;the total effective rate of treatment in the observation group was higher than that in the control group,and the rebleeding rate was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of serum interleukin-6(IL-6)and gastrin(GAS)of the two groups were lower than those before treatment,the levels of epidermal growth factor(EGF)and vascular endothelial growth factor(VEGF)were higher than those before treatment,and the levels of IL-6 and GAS in the observation group were lower than those in the control group,the levels of EGF and VEGF were higher than those in the control group,the differences were statistically significant(P<0.05).After 1 month of treatment,the hemostasis time and gastrointestinal symptoms disappearance in the observation group were shorter than those in the control group,and the differencse were statistically significant(P<0.05).The incidence of adverse reactions in the observa-tion group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ilaprazole so-dium for injection has a significant therapeutic effect on patients with peptic ulcer bleeding,and it is safe and reliable,which is conducive to promot-ing the recovery of the disease,which is worthy of clinical promotion and application.