康柏西普联合激光光凝对视网膜静脉阻塞伴黄斑水肿患者视力恢复及眼底荧光造影结果的影响

Effect of conbercept combined with laser photocoagulation on visual acuity recovery and fundus fluorescein angiography in patients with retinal vein occlusion complicated with macular edema

目的探讨康柏西普联合激光光凝在视网膜静脉阻塞(RVO)伴黄斑水肿患者中的应用价值。方法选取2020年1月至2022年1月丹江口市第一医院收治的102例RVO伴黄斑水肿患者作为研究对象,按照随机数字表法分为对照组与研究组,每组51例。对照组给予激光光凝治疗,研究组在对照组基础上加用康柏西普治疗,治疗后随访3个月。比较两组临床疗效、最佳矫正视力(BCVA)、黄斑中心视网膜厚度(CMT)、黄斑阈值敏感度(MTS)、眼底荧光造影(囊样渗透、弥漫渗透、局部渗透)及不良反应发生情况。结果研究组治疗总有效率为96.08%,高于对照组的82.35%,差异有统计学意义(P<0.05)。治疗后3个月,两组BCVA、MTS均高于治疗前,CMT均薄于治疗前,且研究组BCVA、MTS均高于对照组,CMT薄于对照组,差异有统计学意义(P<0.05)。研究组眼底荧光造影结果总发生率为3.92%,低于对照组的31.37%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论康柏西普联合激光光凝治疗RVO伴黄斑水肿患者疗效确切,能消除黄斑水肿,提升MTS,减少视网膜渗透,改善患者视力,且安全可行,临床应用价值较高。

Objective To investigate the Effect of conbercept combined with laser photocoagulation on visual acuity recovery and fundus fluo-rescein angiography in patients with retinal vein occlusion(ROV)complicated with macular edema.Methods 102 patients with RVO and macular edema admitted to Danjiangkou First Hospital from January 2020 to January 2022 were selected as the research subjects,they were divided into the control group and the study group according to the random number table method,with 51 cases in each group.The control group was treated with la-ser photocoagulation,and the study group was treated with conbercept on the basis of the control group.The patients were followed up for 3 months after treatment.The clinical efficacy,best corrected visual acuity(BCVA),central macular thickness(CMT),macular threshold sensitivity(MTS),fundus fluorescein angiography(cystic infiltration,diffuse infiltration,local infiltration)and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 96.08%,which was higher than 82.35%in the control group,the differ-ence was statistically significant(P<0.05).At 3 months after treatment,the BCVA and MTS of the two groups were higher than those before treat-ment,and the CMT was thinner than that before treatment,and the BCVA and MTS in the study group were higher than those of the control group,and the CMT was thinner than that in the control group,the differences were statistically significant(P<0.05).The total incidence of fundus fluores-cein angiography in the study group was 3.92%,which was lower than 31.37%in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Conbercept combined with la-ser photocoagulation is effective in the treatment of RVO patients with macular edema,it can eliminate macular edema,improve MTS,reduce retinal penetration,and improve patients'vision,it is safe and feasible,and has high clinical application value.