长脉宽1064 nm Nd:YAG激光与2940 nm Er:YAG激光联合胶原蛋白水光注射在面部年轻化中的临床应用

Clinical application of 1064 nm Nd:YAG laser and 2940 nm Er:YAG laser combined with collagen hydrographic injection in facial rejuvenation

目的运用左右半脸对照(Split-Face)模式评价长脉宽1064 nm Nd:YAG激光与2940 nm Er:YAG激光联合胶原蛋白对于面部年轻化的有效性和安全性。方法本研究共纳入35例有面部年轻化治疗需求的受试者,将其面部随机分为对照侧和治疗侧。对照侧使用1064 nm Nd:YAG激光与2940 nm Er:YAG激光治疗,治疗侧在激光治疗的基础上联合胶原蛋白水光注射,并分别于治疗前及治疗后2周、4周、8周、12周比较两侧面部年轻化程度的差异。结果治疗侧皮肤回弹时间、皮肤弹性指数、真皮厚度、皮肤亮度、皮肤含水量、经表皮水丢失与治疗前相比差异均有统计学意义(P<0.05);对照侧皮肤回弹时间、真皮厚度、皮肤亮度、皮肤含水量、经表皮水丢失与治疗前相比差异均有统计学意义(P<0.05);两侧面部治疗前各指标之间无统计学差异,治疗后2周开始,两侧面部的皮肤厚度相比差异均有统计学意义(P<0.01);治疗后8周开始,两侧面部的皮肤回弹时间及皮肤弹性指数显示差异均有统计学意义(P<0.05);两侧面部皮肤亮度、皮肤含水量及经表皮水丢失在各时间点相比,差异均无统计学意义(P>0.05)。结论长脉宽1064 nm Nd:YAG激光与2940 nm Er:YAG激光治疗后随即使用胶原蛋白水光注射,协同增效,可以达到即刻补充及持续促进胶原蛋白再生的治疗效果。

Objective Evaluate the effectiveness of Fotona 4D Pro combined with collagen intradermal injection in facial rejuvenation using split face mode.Methods This study included 35 subjects with a need for facial rejuvenation treatment,and their faces were randomly divided into control side and treatment side.The control side was treated with Fotona 4D Pro,while the treatment side was treated with Fotona 4D Pro combined with Fillderm collagen intradermal injection.The differences in the degree of facial rejuvenation on both sides were compared before treatment and at 2,4,8,and 12 weeks after treatment.Results The skin retraction time,skin elasticity index,dermal thickness,skin brightness,skin moisture content and transepidermal water loss on the treatment side were significantly different from those before treatment(P<0.05);The skin retraction time,dermal thickness,skin brightness,skin moisture content and transepidermal water loss of the control side were significantly different from those before treatment(P<0.05);There was no signifificant difference between the two sides of the face in basline,but there was a signifificant difference in the skin thickness between the two sides of the face from 2 weeks after treatment(P<0.01);After 8 weeks of treatment,there were statistically signifificant differences in skin rebound time and skin elasticity index on both sides of the face(P<0.05);There was no statistically signifificant difference in skin brightness,skin moisture content,and transepidermal water loss between the two sides of the face at different time points(P>0.05).Conclusions After treatment with Fotona 4D Pro,collagen intradermal injection can be used immediately to achieve synergistic effects,immediate supplementation,and sustained promotion of collagen regeneration。