不同化学型樟树中萜类成分及药理活性的研究进展

Research progress in terpenoids and their pharmacological activities in different chemotypes of Cinnamomum Camphora

5种化学型樟树在医药、化工、香精香料等领域具有重要的价值,这与其含有丰富的萜类成分密切相关。经统计,在5种化学型樟树中已报道的萜类成分共有184种,包括单萜94种、倍半萜88种和二萜2种,这些萜类化合物中除了共有成分7种以外,特有成分油樟型樟树有18种、脑樟型樟树有7种、芳樟型樟树有27种、龙脑樟型樟树有41种以及异樟型樟树有25种。5种化学型樟树具有抗菌、抗炎、抗肿瘤和抗病毒等作用,因此备受人们的关注。本文对近30年5种化学型樟树中萜类成分及药理活性研究进行总结分析,并对其萜类化合物的药物开发进行讨论与展望,以期为不同化学型樟树的深入研究与开发提供参考。

Different chemotypes of Cinnamomum Camphora have important medicinal values,and also in chemical industry,flavor and fragrance seletion,which is closely related to their rich terpenoids.According to statistics,184 terpenes have been reported in 5 camphor trees,including 94 monoterpenes,88 sesquiterpenes and 2 diterpenes.In addition to 7 common components,there are also 18 cineol types,7 cineol types,27 linalod types,41 bornecol types,and 25 isonerolidol types.The terpenes reported in different chemotypes of Cinnamomum Camphora mainly include monoterpenes,sesquiterpenes,and diterpenes,most showing anti-bacterial,anti-inflammatory,anti-cancer,and anti-flu virus effects.Terpenoids of different chemotypes of Cinnamomum Camphora have attracted much attention.This review summarized terpenoids and their pharmacological activities in different chemotypes of Cinnamomum Camphora in the past 30 years and analyzed;the research and development of terpenoids was discussed to provide reference for further development of chemotypes of Cinnamomum Camphora.