透明质酸修饰血清白蛋白纳米粒在肿瘤诊疗中的研究进展

Advances of hyaluronic acid-modified serum albumin nanoparticles in the diagnosis and treatment of cancer

传统检测和治疗肿瘤的方法存在局限性,如靶向性不足、灵敏度有限等。科学家们开发出的一种新型纳米系统,即利用透明质酸修饰血清白蛋白构建一种生物相容性和降解性都得到改善的纳米系统,有望提供一种新的肿瘤诊疗方法。此外,该纳米系统还具有独特的双重靶向效应,可间接提高肿瘤成像的灵敏度和治疗的准确性。本文旨在探讨透明质酸血清白蛋白纳米粒在肿瘤成像诊断、治疗和治疗一体化应用中的最新研究进展,并指出现阶段仍面临的挑战及须解决的问题,进而为抗肿瘤靶向纳米制剂的开发提供理论依据及方法指导。

The conventional methods of tumor detection and treatment have limitations,such as inadequate targeting and limited sensitivity.However,scientists have developed a new nanosystem that may offer a solution.They have modified the serum albumin with hyaluronic acid,resulting in a nanosystem with improved biocompatibility and degradability.This nanosystem has a unique dualtargeting effect,which can indirectly enhance tumor imaging sensitivity and therapeutic accuracy.This article discussed the most recent advances in hyaluronic acid-modified serum albumin nanoparticle research on tumor imaging diagnosis,treatment,and therapeutic integration,based on domestic and international literatures.It also identified the challenges that still need to be addressed,offered theoretical support and methodological guidance for the development of targeted anti-tumor nano-formulations.