卡前列甲酯栓联合卡前列素氨丁三醇治疗前置胎盘产后出血患者的效果

Effects of Carboprost methylate suppositories combined with Carboprost tromethamine in treatment of postpartum hemorrhage in patients with placenta previa

目的:观察卡前列甲酯栓联合卡前列素氨丁三醇治疗前置胎盘产后出血患者的效果。方法:选取2021年4月至2023年4月该院收治的80例前置胎盘产后出血患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各40例。对照组采用卡前列素氨丁三醇治疗,研究组在对照组基础上联合卡前列甲酯栓治疗,比较两组止血效果、围产期指标水平,治疗前后凝血功能指标[凝血酶原时间(PT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]水平,以及不良反应发生率。结果:研究组止血总有效率为92.50%(37/40),高于对照组的75.00(30/40),差异有统计学意义(P<0.05);研究组产后2、24 h出血量均少于对照组,恶露持续时间和出血减少时间均短于对照组,宫缩持续时间均长于对照组,差异有统计学意义(P<0.05);治疗后,两组FIB水平均高于治疗前,且研究组高于对照组,两组APTT、TT和PT均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡前列甲酯栓联合卡前列素氨丁三醇治疗前置胎盘产后出血患者可提高止血总有效率,改善围产期指标和凝血功能指标水平,其效果优于单纯卡前列素氨丁三醇治疗。

Objective:To observe effects of Carboprost methylate suppositories combined with Carboprost tromethamine in treatment of postpartum hemorrhage in patients with placenta previa.Methods:A prospective study was conducted on 80 postpartum hemorrhage patients with of placenta previa admitted to the hospital from April 2021 to April 2023.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with Carboprost tromethamine,while the study group was treated with Carboprost methylate suppositories on the basis of that of the control group.The hemostatic effect,the perinatal index levels,the coagulation function indexes[prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of hemostasis in the study group was 92.50%(37/40),which was higher than 75.00%(30/40)in the control group,the difference was statistically significant(P<0.05).The amount of bleeding 2 and 24 h after delivery in the study group were less than those in the control group,the duration of lochia and the bleeding reduction time were shorter than those in the control group,the duration of uterine contraction were longer than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the FIB levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of APTT,TT and PT in the two groups were shorter than those before the treatment,and those in the study group were shorter than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carboprost methylate suppositories combined with Carboprost tromethamine in the treatment of the postpartum hemorrhage patients with placenta previa can improve the total effective rate of hemostasis and improve the levels of perinatal indexes and coagulation function indicators.Moreover,it is superior to simple Carboprost tromethamine treatment.