米非司酮与孕三烯酮治疗子宫内膜异位症手术患者的效果比较

Comparison of effects of Mifepristone and Gestrinone in treatment of patients with endometriosis surgery

目的:比较米非司酮与孕三烯酮治疗子宫内膜异位症手术患者的效果。方法:选取2021年5月至2022年5月该院收治的120例子宫内膜异位症患者进行前瞻性研究,根据随机数字表法将其分为对照组和观察组各60例。两组均行腹腔镜手术切除病灶,术后对照组采用孕三烯酮胶囊口服治疗,观察组采用米非司酮片口服治疗。比较两组临床疗效,治疗前后卵巢功能指标(促黄体生成素、雌二醇、促卵泡激素、催乳素、孕酮)水平、疾病相关指标[胱天蛋白酶-3(caspase-3)、细胞因子信号传导抑制蛋白-3(SOCS-3)、血管内皮生长因子(VEGF)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.67%(58/60),高于对照组的78.33%(47/60),差异有统计学意义(P<0.05);治疗后,两组促黄体生成素水平均高于治疗前,且观察组高于对照组,两组雌二醇、促卵泡激素、催乳素、孕酮水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清caspase-3、SOCS-3水平均高于治疗前,且观察组高于对照组;两组血清VEGF水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:米非司酮治疗子宫内膜异位症手术患者可提高治疗总有效率,改善卵巢功能指标和疾病相关指标水平,降低不良反应发生率,其效果优于孕三烯酮治疗。

Objective:To compare effects of Mifepristone and Gestrinone in treatment of patients with endometriosis surgery.Methods:A prospective study was conducted on 120 patients with endometriosis admitted to the hospital from May 2021 to May 2022.According to the random number table method,they were divided into control group and observation group,60 cases in each group.Both groups underwent laparoscopic surgery to remove the lesion.After the surgery,the control group was treated with Gestrinone capsules orally,while the observation group was treated with Mifepristone tablets orally.The clinical efficacy,the ovarian function indexes(luteinizing hormone,estradiol,follicle stimulating hormone,prolactin,progesterone)levels,the disease-related indexes[caspase-3,suppressor of cytokine signaling-3(SOCS-3),vascular endothelial growth factor(VEGF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(58/60),which was higher than 78.33%(47/60)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of luteinizing hormone in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of estradiol,follicle stimulating hormone,prolactin and progesterone in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).After the treatment,the levels of serum caspase-3 and SOCS-3 in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the serum VEGF levels of the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Mifepristone in the treatment of the patients with endometriosis surgery can improve the total effective rate of treatment,improve the levels of ovarian function indexes and disease-related indexes,and reduce the incidence of adverse reactions.Moreover,it is superior to simple Gestrinone treatment.