聚乳酸-羟基乙酸材料修复骨缺损的研究进展

Research progress of poly(lacticco-glycolic acid)materials in repairing bone defect

随着骨组织工程的发展,3D打印高分子材料和生物相容性支架等骨修复材料成为骨缺损修复的研究热点,其中,聚乳酸-羟基乙酸共聚物(polylactic-co-glycolic acid,PLGA)因具有良好的可塑性、生物相容性和降解性,被广泛应用于骨缺损修复材料的研究,是骨缺损修复的理想材料。但其力学性能较差、缺乏促成骨性能、降解后局部微环境呈弱酸性等缺点限制了其在骨缺损修复方面的应用,因此,将其与不同材料相复合进行修饰改性显得尤为重要。本文以PLGA的理化性质、降解机制为基础,综述了其与药物、生物分子、无机材料、有机材料相复合的研究,为未来在临床中大量应用该材料提供借鉴和理论支撑。

With the development of bone tissue engineering,bone repair materials such as 3D printed polymer materials and biocompatible scaffolders have become a research hotspot in the restoration of bone defects.Among them,poly(lactic acidco-glycolic acid)(PLGA)has good plasticity,biocompatibility and degradability.It is widely used in the research of bone defect repair materials and is an ideal material for bone defect repair.However,its application in repairing bone defects is limited by its poor mechanical properties,lack of osteogenic properties,weak acidity of local microenvironment after degradation,etc.Therefore,it is particularly important to compound it with different materials for modification.Based on the physicochemical properties and degradation mechanism of PLGA,this paper reviews the research on its composite with drugs,biomolecules,inorganic materials and organic materials,providing reference and theoretical support for the future clinical application of this material.