摘要
A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.
基金
supported by the German Research Foundation(INST 248/331-1 FUGG,FA1034/3-3,project number 258652740,FA 1034/6-1,project number 496762016,FA1034/8-1,project number 527664508)
Kooperation Phytopharmaka GbR,Bonn,Germany(TU-KL#2)
the European Partnership for the Assessment of Risks from Chemicals(PARC)under the Horizon Europe Research and Innovation Programme,Grant Agreement No.101057014.
