肥胖相关肾病的发病机制及营养治疗进展

Mechanism and nutritional therapy of obesity related kidney disease

我国成年居民肥胖患病率呈上升趋势,肥胖与肾脏病的发生、发展密切相关。其发病机制可能与肥胖引起肾小球高滤过、肾素-血管紧张素-醛固酮系统过度激活、机体慢性炎症、高胰岛素血症和胰岛素抵抗、异位脂质积累和脂毒性等相关。营养治疗,包括营养素摄入、食物的选择以及膳食方案的制定,是肥胖相关肾病治疗的基石及重要组成部分,除此之外还有药物及减重手术等治疗方式。

The rate of obesity among adult in China is on the rise,and obesity is closely related to the incidence and progression of kidney disease.The mechanism of its occurrence may be related to glomerular hyperfiltration,excessive activation of the renin angiotensin aldosterone system,chronic inflammation of the body,hyperinsulinemia and insulin resistance,ectopic lipid accumulation,and lip toxicity.Nutritional therapy,including nutrient intake,food selection,and the development of dietary plans,is the cornerstone and important component of obesity related kidney disease treatment,in addition to medication and weight loss surgery.