摘要
The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of TBC.Water-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.
基金
supported by the National Natural Science Foundation of China(Grant No.:82130113)
the National Key R&D Program of China(Program No.:2023YFC3504402)
the China Postdoctoral Science Foundation(Grant No.:2021MD703800)
the Science Foundation for Youths of Science&Technology Department of Sichuan Province(Grant Nos.:2023NSFSC1775,2022NSFSC1449)
the“Xinglin Scholars”Research Promotion Program of Chengdu University of TCM(Grant Nos.:BSH2021009,QJRC2022044).
