《世界卫生组织结核病整合指南模块3:诊断——结核病检测的快速诊断》第三版解读

Interpretation of the third edition of WHO consolidated guidelines on tuberculosis:module 3:diagnosis:rapid diagnostics for tuberculosis detection

2024年3月20日,世界卫生组织发布了《世界卫生组织结核病整合指南模块3:诊断——结核病检测的快速诊断》(第三版)。指南主要针对3个方面提出建议:耐药结核病的初始诊断检测方法、结核病的初始诊断检测方法(不包括耐药性检测)和结核病确诊后的耐药性检测。另外,指南首次增加靶向高通量测序(targeted next-generation sequencing,tNGS)技术可用于针对结核病确诊后耐药性检测的推荐意见。笔者对第三版指南的编制及内容要点加以解读,以促进该指南更好地实施与推广。

On 20 March 2024,the World Health Organization(WHO)published the WHO consolidated guidelines on tuberculosis:Module 3:diagnosis:rapid diagnostics for tuberculosis detection.The third edition of the guidelines focuses on three areas:initial diagnostic tests for diagnosis of tuberculosis with drug-resistance detection,initial diagnostic tests for diagnosis of tuberculosis without drug-resistant detection,and follow-on diagnostic tests for detection of additional drug-resistance after tuberculosis confirmation.In addition,this current guidelines include for the first time a chapter on targeted next generation sequencing(tNGS)tests for the diagnosis of drug-resistant tuberculosis in people with diagnosed tuberculosis with or without rifampicin-resistant tuberculosis.The author now introduces the compilation and key points of the third edition of the guidelines in order to promote the implementation and dissemination of these guidelines.