肿瘤类器官临床前转化研究及应用

Preclinical translational research and application of tumor organoids

越来越深入的肿瘤机制研究和临床精准治疗对肿瘤模型的建立提出了更高的要求,肿瘤类器官应用越来越广泛。该模型被认为可以再现亲代肿瘤的基因组、转录组、蛋白质组等多组学特征,具有细胞系模型所缺乏的异质性。基于这些特征,肿瘤类器官逐渐成为一个具有代表性的临床前模型,助力于新的研究成果转化以及患者的精准治疗。本文将从肿瘤类器官的研究及应用的角度总结其最新进展,重点关注当前建立肿瘤类器官方法以及应用中所面临的机遇和挑战。

More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied.This model is able to reproduce the genomic,transcriptome,proteome and other omics features of parental tumors without heterogeneity found in cell line models.Based on these characteristics,tumor organoids have gradually become a representative preclinical model,facilitating the translation of new research results and precision treatment of patients.This article summarizes the latest progress of tumor organoids on R&D of technology and application,focusing on the current methods of establishing tumor organoids,opportunities and challenges in clinical and research application.